Publication: Inflammation biomarkers and inflammatory genes expression in metabolically healthy obese patients
Program
KU-Authors
KU Authors
Co-Authors
Spoto B.
Di Betta E.
Pizzini P.
Lonardi S.
Mallamaci F.
Tripepi G.
Cancarini G.
Zoccali C.
Advisor
Publication Date
Language
English
Type
Journal Title
Journal ISSN
Volume Title
Abstract
Abstract Backgroundandaims:Obesitywithoutmetabolicalterations(MetabolicallyHealthy Obesity,MHO) isaconditionwithariskofdeathandcardiovasculardiseaselowerthanthat ofobesityassociatedwithmetabolicalterations(MetabolicallyUnhealthyObesity,MUO)and similartothatofhealthynonobeseindividuals. Inflammationisconsideredasakeyriskfactor mediatingtheadversehealthoutcomesinobesity. Methodsandresults:Wecomparedcirculatinglevelsofthirteenmajorcytokinesandadipokines andtheexpressionprofilesoffifteenpro-inflammatoryandtwoanti-inflammatorygenes in visceralandsubcutaneousadiposetissueinaseriesof16MHOpatientsandin32MUOpatients thatunderwentbariatricsurgery.MHOwasdefinedaccordingtothemostapplieddefinitionin current literature. SerumlevelsofalargesetofmajorcytokinesandadipokinesdidnotdifferbetweenMHOand MUOpatients(p 0.15).Analysesof theexpressionprofileofpro-inflammatoryandantiinflammatorygenesinsubcutaneousandvisceraladiposetissuefailedtoshowdifferencesbetweenMHOandMUOpatients(p 0.07).SensitivityanalysesapplyingtwoadditionaldefinitionsofMHOconfirmedtheresultsof theprimaryanalysis. Conclusion: Inaseriesofmetabolicallyhealthyobesepatientsneithercirculatinglevelsofmajor cytokinesandadipokinesnorthegeneexpressionprofileofalargesetofpro-inflammatoryand anti-inflammatorygenesinsubcutaneousandvisceral fatdifferedfromthoseinmetabolically unhealthyobesepatients.
Source:
Nutrition, Metabolism and Cardiovascular Diseases
Publisher:
Elsevier B.V.
Keywords:
Subject
Body mass, High density lipoprotein cholesterol, Metabolic syndrome