Publication: Inflammation biomarkers and inflammatory genes expression in metabolically healthy obese patients
Program
KU-Authors
KU Authors
Co-Authors
Spoto B.
Di Betta E.
Pizzini P.
Lonardi S.
Mallamaci F.
Tripepi G.
Cancarini G.
Zoccali C.
Publication Date
Language
Type
Embargo Status
Journal Title
Journal ISSN
Volume Title
Alternative Title
Abstract
Abstract Backgroundandaims:Obesitywithoutmetabolicalterations(MetabolicallyHealthy Obesity,MHO) isaconditionwithariskofdeathandcardiovasculardiseaselowerthanthat ofobesityassociatedwithmetabolicalterations(MetabolicallyUnhealthyObesity,MUO)and similartothatofhealthynonobeseindividuals. Inflammationisconsideredasakeyriskfactor mediatingtheadversehealthoutcomesinobesity. Methodsandresults:Wecomparedcirculatinglevelsofthirteenmajorcytokinesandadipokines andtheexpressionprofilesoffifteenpro-inflammatoryandtwoanti-inflammatorygenes in visceralandsubcutaneousadiposetissueinaseriesof16MHOpatientsandin32MUOpatients thatunderwentbariatricsurgery.MHOwasdefinedaccordingtothemostapplieddefinitionin current literature. SerumlevelsofalargesetofmajorcytokinesandadipokinesdidnotdifferbetweenMHOand MUOpatients(p 0.15).Analysesof theexpressionprofileofpro-inflammatoryandantiinflammatorygenesinsubcutaneousandvisceraladiposetissuefailedtoshowdifferencesbetweenMHOandMUOpatients(p 0.07).SensitivityanalysesapplyingtwoadditionaldefinitionsofMHOconfirmedtheresultsof theprimaryanalysis. Conclusion: Inaseriesofmetabolicallyhealthyobesepatientsneithercirculatinglevelsofmajor cytokinesandadipokinesnorthegeneexpressionprofileofalargesetofpro-inflammatoryand anti-inflammatorygenesinsubcutaneousandvisceral fatdifferedfromthoseinmetabolically unhealthyobesepatients.
Source
Publisher
Elsevier B.V.
Subject
Body mass, High density lipoprotein cholesterol, Metabolic syndrome
Citation
Has Part
Source
Nutrition, Metabolism and Cardiovascular Diseases
Book Series Title
Edition
DOI
10.1016/j.numecd.2022.12.008