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Inflammation biomarkers and inflammatory genes expression in metabolically healthy obese patients

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SCHOOL OF MEDICINE
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Spoto B.
Di Betta E.
Pizzini P.
Lonardi S.
Mallamaci F.
Tripepi G.
Cancarini G.
Zoccali C.

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Date

2023

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Journal Article

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Abstract

Abstract Backgroundandaims:Obesitywithoutmetabolicalterations(MetabolicallyHealthy Obesity,MHO) isaconditionwithariskofdeathandcardiovasculardiseaselowerthanthat ofobesityassociatedwithmetabolicalterations(MetabolicallyUnhealthyObesity,MUO)and similartothatofhealthynonobeseindividuals. Inflammationisconsideredasakeyriskfactor mediatingtheadversehealthoutcomesinobesity. Methodsandresults:Wecomparedcirculatinglevelsofthirteenmajorcytokinesandadipokines andtheexpressionprofilesoffifteenpro-inflammatoryandtwoanti-inflammatorygenes in visceralandsubcutaneousadiposetissueinaseriesof16MHOpatientsandin32MUOpatients thatunderwentbariatricsurgery.MHOwasdefinedaccordingtothemostapplieddefinitionin current literature. SerumlevelsofalargesetofmajorcytokinesandadipokinesdidnotdifferbetweenMHOand MUOpatients(p 0.15).Analysesof theexpressionprofileofpro-inflammatoryandantiinflammatorygenesinsubcutaneousandvisceraladiposetissuefailedtoshowdifferencesbetweenMHOandMUOpatients(p 0.07).SensitivityanalysesapplyingtwoadditionaldefinitionsofMHOconfirmedtheresultsof theprimaryanalysis. Conclusion: Inaseriesofmetabolicallyhealthyobesepatientsneithercirculatinglevelsofmajor cytokinesandadipokinesnorthegeneexpressionprofileofalargesetofpro-inflammatoryand anti-inflammatorygenesinsubcutaneousandvisceral fatdifferedfromthoseinmetabolically unhealthyobesepatients.

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Elsevier B.V.

Subject

Body mass, High density lipoprotein cholesterol, Metabolic syndrome

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Nutrition, Metabolism and Cardiovascular Diseases

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DOI

10.1016/j.numecd.2022.12.008

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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85146479346&doi=10.1016%2fj.numecd.2022.12.008&partnerID=40&md5=31490af6be45fcdcebbc231bb14ada4e
 https://hdl.handle.net/20.500.14288/6480

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02 - Zero Hunger
Hunger is the leading cause of death in the world. Our planet has provided us with tremendous resources, but unequal access and inefficient handling leaves millions of people malnourished. If we promote sustainable agriculture with modern technologies and fair distribution systems, we can sustain the whole world’s population and make sure that nobody will ever suffer from hunger again.
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03 - Good Health and Well-being
Over the last 15 years, the number of childhood deaths has been cut in half. This proves that it is possible to win the fight against almost every disease. Still, we are spending an astonishing amount of money and resources on treating illnesses that are surprisingly easy to prevent. The new goal for worldwide Good Health promotes healthy lifestyles, preventive measures and modern, efficient healthcare for everyone.

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