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Inflammation biomarkers and inflammatory genes expression in metabolically healthy obese patients

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dc.contributor.coauthorSpoto B.
dc.contributor.coauthorDi Betta E.
dc.contributor.coauthorPizzini P.
dc.contributor.coauthorLonardi S.
dc.contributor.coauthorMallamaci F.
dc.contributor.coauthorTripepi G.
dc.contributor.coauthorCancarini G.
dc.contributor.coauthorZoccali C.
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorKanbay, Mehmet
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T22:49:24Z
dc.date.issued2023
dc.description.abstractAbstract Backgroundandaims:Obesitywithoutmetabolicalterations(MetabolicallyHealthy Obesity,MHO) isaconditionwithariskofdeathandcardiovasculardiseaselowerthanthat ofobesityassociatedwithmetabolicalterations(MetabolicallyUnhealthyObesity,MUO)and similartothatofhealthynonobeseindividuals. Inflammationisconsideredasakeyriskfactor mediatingtheadversehealthoutcomesinobesity. Methodsandresults:Wecomparedcirculatinglevelsofthirteenmajorcytokinesandadipokines andtheexpressionprofilesoffifteenpro-inflammatoryandtwoanti-inflammatorygenes in visceralandsubcutaneousadiposetissueinaseriesof16MHOpatientsandin32MUOpatients thatunderwentbariatricsurgery.MHOwasdefinedaccordingtothemostapplieddefinitionin current literature. SerumlevelsofalargesetofmajorcytokinesandadipokinesdidnotdifferbetweenMHOand MUOpatients(p 0.15).Analysesof theexpressionprofileofpro-inflammatoryandantiinflammatorygenesinsubcutaneousandvisceraladiposetissuefailedtoshowdifferencesbetweenMHOandMUOpatients(p 0.07).SensitivityanalysesapplyingtwoadditionaldefinitionsofMHOconfirmedtheresultsof theprimaryanalysis. Conclusion: Inaseriesofmetabolicallyhealthyobesepatientsneithercirculatinglevelsofmajor cytokinesandadipokinesnorthegeneexpressionprofileofalargesetofpro-inflammatoryand anti-inflammatorygenesinsubcutaneousandvisceral fatdifferedfromthoseinmetabolically unhealthyobesepatients.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue3
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume33
dc.identifier.doi10.1016/j.numecd.2022.12.008
dc.identifier.issn0939-4753
dc.identifier.quartileQ2
dc.identifier.scopus2-s2.0-85146479346
dc.identifier.urihttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85146479346&doi=10.1016%2fj.numecd.2022.12.008&partnerID=40&md5=31490af6be45fcdcebbc231bb14ada4e
dc.identifier.urihttps://hdl.handle.net/20.500.14288/6480
dc.identifier.wos990336000001
dc.keywordsObesity
dc.keywordsMetabolically healthy obesity
dc.keywordsCytokines
dc.keywordsVisceral adipose tissue
dc.keywordsSubcutaneous adipose tissue
dc.keywordsGene expression
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofNutrition, Metabolism and Cardiovascular Diseases
dc.subjectBody mass
dc.subjectHigh density lipoprotein cholesterol
dc.subjectMetabolic syndrome
dc.titleInflammation biomarkers and inflammatory genes expression in metabolically healthy obese patients
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorKanbay, Mehmet
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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relation.isOrgUnitOfPublication.latestForDiscoveryd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

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