Publication: Myelin oligodendrocyte glycoprotein antibodies in genetic leukodystrophies
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KU Authors
Co-Authors
EroÄlu ErtuÄrul, Nesibe Gevher
Pekgüzel, Faruk
Guenbey, Ceren
TopƧu, Meral
OÄuz, Kader K.
Ćzkara, Hatice Asuman
Anlar, Banu
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Abstract
Accumulation of intermediate metabolites due to enzyme deficiencies and demyelination can provoke inflammation in genetic leukodystrophies. Thirty patients with genetic leukodystrophy and 48 healthy control sera were tested for anti-myelin oligodendrocyte glycoprotein (MOG) antibodies by fixed and/or live cell-based assays. MOG-IgG was detected in two late infantile metachromatic leukodystrophy (MLD) cases, both of which were also weakly positive for IgG1, and one with IgG3 as the dominant anti-MOG IgG subclass. MOG-IgG was borderline positive in a vanishing white matter (VWM) disease patient. These results suggest that inherited metabolic or degenerative processes can have an autoimmune component, possibly as an epiphenomenon.
Source
Publisher
Elsevier
Subject
Immunology, Neurosciences
Citation
Has Part
Source
Journal of Neuroimmunology
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Edition
DOI
10.1016/j.jneuroim.2022.577916