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Treatment of leukoplakia with aminolevulinic acid–photodynamic therapy for resistant and dysplastic lesions

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dc.contributor.departmentKUH (Koç University Hospital)
dc.contributor.kuauthorÇelebi, Özlem Önerci
dc.contributor.schoolcollegeinstituteKUH (KOÇ UNIVERSITY HOSPITAL)
dc.date.accessioned2026-08-14T11:27:49Z
dc.date.issued2026
dc.description.abstractIdeal treatment outcomes for vocal fold leukoplakia include the complete removal of diseased epithelium with minimal vocal fold scarring and preservation of vocal quality. Aminolevulinic acid (ALA) Photodynamic Therapy (PDT) is a promising novel technique described in this chapter that may better realize these ideal treatment outcomes. After topical application of ALA, the porphyrin-heme biosynthesis pathway converts the ALA, leading to the accumulation of protoporphyrin IX, a photosensitizing agent, in the mitochondria. A laser is used to precisely activate the protoporphyrin IX to target its lethal cellular effects in the diseased tissue. Over the past 24 years, ALA-PDT has been a safe and effective technique for the treatment of glottal dysplasia.
dc.description.harvestedfromManual
dc.description.indexedbyScopus
dc.description.publisherscopeInternational
dc.description.readpublishN/A
dc.description.sponsoredbyTubitakEuN/A
dc.description.versionPublished Version
dc.identifier.ScopusPercentileN/A
dc.identifier.ScopusQuartileN/A
dc.identifier.WoSPercentileN/A
dc.identifier.WoSQuartileN/A
dc.identifier.doi10.1016/b978-0-443-10617-0.00040-x
dc.identifier.embargoN/A
dc.identifier.endpage242
dc.identifier.isbn9780443106170
dc.identifier.isbn9780443106354
dc.identifier.scopus2-s2.0-105035278526
dc.identifier.startpage236
dc.identifier.urihttp://doi.org/10.1016/b978-0-443-10617-0.00040-x
dc.identifier.urihttps://hdl.handle.net/20.500.14288/34680
dc.keywordsALA-PDT
dc.keywordsAngiolytic laser
dc.keywordsDysplasia
dc.keywordsLaryngeal leukoplakia
dc.keywordsLeukoplakia
dc.keywordsPhotodynamic therapy
dc.languageeng
dc.publisherElsevier
dc.relation.affiliationKoç University
dc.relation.collectionKoç University Institutional Repository
dc.relation.ispartofOffice-Based Surgical Procedures in Otolaryngology
dc.relation.openaccessN/A
dc.rightsN/A
dc.rights.uriN/A
dc.subjectOtolaryngology
dc.subjectHead and neck surgery
dc.titleTreatment of leukoplakia with aminolevulinic acid–photodynamic therapy for resistant and dysplastic lesions
dc.typeBook Chapter
dspace.entity.typePublication
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relation.isParentOrgUnitOfPublication.latestForDiscovery055775c9-9efe-43ec-814f-f6d771fa6dee

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