Publication:
Effect of human papillomavirus subtype on the rate of positive surgical margin after cervical conization

dc.contributor.coauthorPurut, Yunus Emre
dc.contributor.coauthorAkis, Serkan
dc.contributor.coauthorPeker, Esra Keles
dc.contributor.coauthorBabayeva, Gulchin
dc.contributor.coauthorKabaca, Canan
dc.contributor.coauthorApi, Murat
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorGiray, Burak
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T23:00:44Z
dc.date.issued2023
dc.description.abstractObjective. Human papillomavirus (HPV) infection is a risk factor for cervical carcinoma. Over 100 types of HPV have been identified. The excisional procedures are recommended for women with high-grade cervical intraepithelial neoplasia. Surgical margin status is an important predictor of the risk of relapse. The aim of the current study was to evaluate whether HPV genotype is a predictive factor of positive surgical margin after cervical cone excision. Materials and Methods. The records of 448 HPV-infected patients who underwent loop electrosurgical excision or cold knife conization at a tertiary gynecological cancer center were retrospectively reviewed. The patients were divided into 6 groups according to HPV positivity: HPV 16 only, HPV 18 only, HPV 16/18, other high-risk HPV (hrHPV), HPV 16/hrHPV, and HPV 18/hrHPV. Results. There was no significant difference between the HPV groups in terms of age, parity, menopausal status, endocervical canal involvement, conization method, and the rates of positive margin (P = .15, P = .49, P = .07, P = .20, P = .24, P = .39, respectively). Conclusion. The results show that HPV subtypes might not be associated with endocervical canal involvement and the rates of positive margin. In addition, margin status was not related to the conization method and the number of excised cervical tissue.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.issue1
dc.description.openaccessNO
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume31
dc.identifier.doi10.1177/10668969221143460
dc.identifier.eissn1940-2465
dc.identifier.issn1066-8969
dc.identifier.quartileQ3
dc.identifier.scopus2-s2.0-85144181499
dc.identifier.urihttps://doi.org/10.1177/10668969221143460
dc.identifier.urihttps://hdl.handle.net/20.500.14288/8113
dc.identifier.wos898297500001
dc.keywordsCervical intraepithelial neoplasia
dc.keywordsConization
dc.keywordsHuman papillomavirus
dc.keywordsLoop electrosurgical excision intraepithelial neoplasia
dc.keywordsResidual disease
dc.keywordsPre-conization
dc.keywordsHPV infection
dc.keywordsRisk-factors
dc.keywordsDNA load
dc.keywordsAssociation
dc.keywordsPersistence
dc.keywordsLesions
dc.keywordsWomen
dc.language.isoeng
dc.publisherSage
dc.relation.ispartofInternational Journal of Surgical Pathology
dc.subjectPathology
dc.subjectSurgery
dc.titleEffect of human papillomavirus subtype on the rate of positive surgical margin after cervical conization
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorGiray, Burak
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

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