Publication:
Exendin-4 as a versatile therapeutic agent for the amelioration of diabetic changes

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dc.contributor.coauthorAhmadi, Mahdi
dc.contributor.coauthorAslani, Somayeh
dc.contributor.coauthorSaberianpour, Shirin
dc.contributor.coauthorRahbarghazi, Reza
dc.contributor.kuauthorRajabi, Hadi
dc.contributor.kuprofileFaculty Member
dc.contributor.researchcenterKoç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM)
dc.contributor.schoolcollegeinstituteGraduate School of Health Sciences
dc.date.accessioned2024-11-09T12:12:19Z
dc.date.issued2022
dc.description.abstractType 2 diabetes mellitus (T2DM) is a chronic metabolic abnormality leading to microvascular and macrovascular complications. Non-insulin Incretin mimic synthetic peptide exendin-4 was introduced as an anti-diabetic drug which helped diabetic patients with triggering insulin secretion; further researches have revealed an effective role of exendin-4 in treatment of T2DM related diseases. Exendin-4 is approximately similar to Glucagon like peptide, thus it can bind to the glucagon-like peptide-1 receptor (GLP-1R) and activated different signaling pathways that are involved in various bioactivides such as apoptosis, insulin secretion and inactivation of microglial. In this review, we investigated the interesting role of exendin-4 in various kinds of T2DM related disorders through the activation of different signaling pathways.
dc.description.fulltextYES
dc.description.indexedbyWoS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue2
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipN/A
dc.description.versionPublisher version
dc.description.volume12
dc.formatpdf
dc.identifier.doi10.34172/apb.2022.025
dc.identifier.eissn2251-7308
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR03520
dc.identifier.issn2228-5881
dc.identifier.linkhttps://doi.org/10.34172/apb.2022.025
dc.identifier.quartileN/A
dc.identifier.scopus2-s2.0-85128166956
dc.identifier.urihttps://hdl.handle.net/20.500.14288/1154
dc.identifier.wos768125100004
dc.keywordsDiabetes complications
dc.keywordsExendin-4
dc.keywordsSignaling pathways
dc.languageEnglish
dc.publisherTabriz University of Medical Sciences
dc.relation.grantnoNA
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/10315
dc.sourceAdvanced Pharmaceutical Bulletin
dc.subjectPharmacology and pharmacy
dc.titleExendin-4 as a versatile therapeutic agent for the amelioration of diabetic changes
dc.typeReview
dspace.entity.typePublication
local.contributor.kuauthorRajabi, Hadi

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