Publication:
The role of social support on cognitive function among midlife and older adult MSM

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Henderson, Emmett R.
Haberlen, Sabina A.
Coulter, Robert W. S.
Weinstein, Andrea M.
Meanley, Steven
Brennan-Ing, Mark
Mimiaga, Matthew J.
Turan, Janet M.
Teplin, Linda A.
Egan, James E.

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Publication Date

2023

Language

en

Type

Journal article

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Abstract

Objective:This study examines the association between social support and cognitive function among midlife and older MSM living with or without HIV.Design:We analyzed longitudinal data from participants enrolled from October 2016 to March 2019 in the Patterns of Healthy Aging Study, a substudy of the Multicenter AIDS Cohort Study. Methods: We conducted a cross-sectional analysis to estimate the association between social support and three measures of cognitive function [Trail Making Test (TMT) Part A, TMT Part B to A ratio, and Symbol Digit Modalities Tasks (SDMT)]. We also used linear mixed-effects models to estimate the association between baseline social support and cognitive function across four subsequent time points. We evaluated a multiplicative interaction term between baseline social support and time, in order to determine whether cognitive trajectories over time vary by baseline social support. Results: Social support was associated with lower TMT Part A scores at baseline and over the subsequent 2 years, indicating better psychomotor ability. Social support was associated with higher SDMT scores at baseline and across 2 years, indicating better information processing. We observed no association between social support and TMT B to A ratio at baseline or across 2 years, indicating no effect on set-shifting ability. Longitudinal cognition outcome trajectories did not vary by the level of baseline social support. Conclusion: Social support and cognitive function were associated in this sample over a short time period. Further research should explore causal relationships over the lifespan.

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Source:

AIDS

Publisher:

Lippincott Williams & Wilkins

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Subject

Immunology, Infectious diseases, Virology

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