Publication:
The role of social support on cognitive function among midlife and older adult MSM

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dc.contributor.coauthorHenderson, Emmett R.
dc.contributor.coauthorHaberlen, Sabina A.
dc.contributor.coauthorCoulter, Robert W. S.
dc.contributor.coauthorWeinstein, Andrea M.
dc.contributor.coauthorMeanley, Steven
dc.contributor.coauthorBrennan-Ing, Mark
dc.contributor.coauthorMimiaga, Matthew J.
dc.contributor.coauthorTuran, Janet M.
dc.contributor.coauthorTeplin, Linda A.
dc.contributor.coauthorEgan, James E.
dc.contributor.coauthorPlankey, Michael W.
dc.contributor.coauthorFriedman, M. Reuel
dc.contributor.departmentDepartment of Psychology
dc.contributor.kuauthorTuran, Bülent
dc.contributor.otherDepartment of Psychology
dc.contributor.schoolcollegeinstituteCollege of Social Sciences and Humanities
dc.date.accessioned2024-12-29T09:41:03Z
dc.date.issued2023
dc.description.abstractObjective:This study examines the association between social support and cognitive function among midlife and older MSM living with or without HIV.Design:We analyzed longitudinal data from participants enrolled from October 2016 to March 2019 in the Patterns of Healthy Aging Study, a substudy of the Multicenter AIDS Cohort Study. Methods: We conducted a cross-sectional analysis to estimate the association between social support and three measures of cognitive function [Trail Making Test (TMT) Part A, TMT Part B to A ratio, and Symbol Digit Modalities Tasks (SDMT)]. We also used linear mixed-effects models to estimate the association between baseline social support and cognitive function across four subsequent time points. We evaluated a multiplicative interaction term between baseline social support and time, in order to determine whether cognitive trajectories over time vary by baseline social support. Results: Social support was associated with lower TMT Part A scores at baseline and over the subsequent 2 years, indicating better psychomotor ability. Social support was associated with higher SDMT scores at baseline and across 2 years, indicating better information processing. We observed no association between social support and TMT B to A ratio at baseline or across 2 years, indicating no effect on set-shifting ability. Longitudinal cognition outcome trajectories did not vary by the level of baseline social support. Conclusion: Social support and cognitive function were associated in this sample over a short time period. Further research should explore causal relationships over the lifespan.
dc.description.indexedbyWoS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue5
dc.description.openaccessGreen Submitted, Green Accepted
dc.description.publisherscopeInternational
dc.description.sponsorsThe authors are indebted to the participants of the MACS Healthy Aging Study. The authors thank the staff at the four sites for implementation support, and they thank John Welty, Montserrat Tarrago, and Katherine McGo-wan for data support in this study. This work was partially supported by the National Institute of Mental Health (T32MH094174 awarded to E.R.H.). De-identified data and coding scripts will be made available for all reasonable requests in keeping with internal procedures of the MWCCS. E.R.H. conceptualized the study, conducted the statistical analysis, and drafted the initial manuscript. S.A.H., R.W. S.C., A.M.W., J.E.E., and M.R.F. contributed to the statistical analysis and manuscript writing. S.M., M.B.-I., M.J.M., J.M.T., B.T., L.A.T., and M.W.P. contributed to data collection and manuscript writing. All authors approved the final version of the manuscript. This study was funded by the National Institute on Minority Health and Health Disparities (grant R01 <EM><STRONG> </STRONG></EM>MD010680; MWP and MRF). The contents of this publication are solely the responsibility of the authors and do not represent the official views of the National Institutes of Health. The Multicenter AIDS Cohort Study (MACS) and the Women's Interagency HIV Study Combined Cohort Study (principal investigators): Atlanta CRS (Ighovwerha Ofotokun, Anandi Sheth, and Gina Wingood), U01-HL146241; Baltimore CRS (Todd Brown and Joseph Margolick), U01-HL146201; Bronx CRS (Kathryn Anastos and Anjali Sharma), U01-HL146204; Brooklyn CRS (Deborah Gustafson and Tracey Wilson), U01-HL146202; data analysis and coordination center (Gypsyamber D'Souza, Stephen Gange, and Elizabeth Golub), U01-HL146193; Chi-cago-Cook County CRS (Mardge Cohen and Audrey French), U01-HL146245; Chicago-Northwestern CRS (Steven Wolinsky), U01-HL146240; Connie Wofsy Women's HIV Study, Northern California CRS (Bradley Aouizerat, Phyllis Tien, and Jennifer Price), U01-HL146242; Los Angeles CRS (Roger Detels), U01-HL146333; Metropolitan Washington CRS (Seble Kassaye and Daniel Merenstein), U01-HL146205; Miami CRS (Maria Alcaide, Margaret Fischl, and Deborah Jones), U01-HL146203; Pittsburgh CRS (Jeremy Mar-tinson and Charles Rinaldo), U01-HL146208; UAB-MS CRS (Mirjam-Colette Kempf, Jodie Dionne-Odom, and Deborah Konkle-Parker), U01-HL146192; and UNC CRS (Adaora Adimora), U01-HL146194. The MACS/Women's Interagency HIV Study (MWCCS) is funded primarily by the National Heart, Lung, and Blood Institute, with additional cofunding from the Eunice Kennedy Shriver National Institute of Child Health & Human Development, National Institute on Aging, National Institute of Dental & Craniofacial Research, National Institute of Allergy and Infectious Diseases, National Institute of Neurological Disorders and Stroke, National Institute of Mental Health, National Institute on Drug Abuse, National Institute of Nursing Research, National Cancer Institute, National Institute on Alcohol Abuse and Alcoholism, National Institute on Deafness and Other Communication Disorders, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute on Minority Health and Health Disparities, and in coordination and alignment with the research priorities of the National Institutes of Health, Office of AIDS Research. MWCCS data collection was also supported by UL1-TR000004 (UCSF CTSA), P30-AI-050409 (Atlanta Center for AIDS Research [CFAR]), P30-AI -050410 (University of North Carolina CFAR), and P30 -AI-027767 (University of Alabama in Birmingham CFAR).
dc.description.volume37
dc.identifier.doi10.1097/QAD.0000000000003464
dc.identifier.eissn1473-5571
dc.identifier.issn0269-9370
dc.identifier.quartileQ2
dc.identifier.scopus2-s2.0-85150176118
dc.identifier.urihttps://doi.org/10.1097/QAD.0000000000003464
dc.identifier.urihttps://hdl.handle.net/20.500.14288/23503
dc.identifier.wos958331000014
dc.keywordsCognitive decline
dc.keywordsHIV
dc.keywordsAIDS
dc.keywordsMSM
dc.keywordsPsychosocial health conditions
dc.keywordsSocial support
dc.languageen
dc.publisherLippincott Williams & Wilkins
dc.relation.grantnoNational Institute of Mental Health [T32MH094174]
dc.relation.grantnoNational Institute on Minority Health and Health Disparities [R01 MD010680]
dc.relation.grantnoNational Institutes of Health
dc.relation.grantnoBaltimore CRS [U01-HL146241]
dc.relation.grantnoBronx CRS [U01-HL146201]
dc.relation.grantnoBrooklyn CRS [U01-HL146204]
dc.relation.grantnoChi-cago-Cook County CRS [U01-HL146202]
dc.relation.grantnoChicago-Northwestern CRS [U01-HL146193]
dc.relation.grantnoConnie Wofsy Women's HIV Study [U01-HL146245]
dc.relation.grantnoNorthern California CRS [U01-HL146240]
dc.relation.grantnoLos Angeles CRS
dc.relation.grantnoMetropolitan Washington CRS [U01-HL146242]
dc.relation.grantnoMiami CRS [U01-HL146333]
dc.relation.grantnoPittsburgh CRS [U01-HL146205]
dc.relation.grantnoUAB-MS CRS [U01-HL146203]
dc.relation.grantnoUNC CRS [U01-HL146208]
dc.relation.grantnoNational Heart, Lung, and Blood Institute [U01-HL146192]
dc.relation.grantnoEunice Kennedy Shriver National Institute of Child Health & Human Development [U01-HL146194]
dc.relation.grantnoNational Institute on Aging
dc.relation.grantnoNational Institute of Dental & Craniofacial Research
dc.relation.grantnoNational Institute of Allergy and Infectious Diseases
dc.relation.grantnoNational Institute of Neurological Disorders and Stroke
dc.relation.grantnoNational Institute of Mental Health
dc.relation.grantnoNational Institute on Drug Abuse
dc.relation.grantnoNational Institute of Nursing Research
dc.relation.grantnoNational Cancer Institute
dc.relation.grantnoNational Institute on Alcohol Abuse and Alcoholism
dc.relation.grantnoNational Institute on Deafness and Other Communication Disorders
dc.relation.grantnoNational Institute of Diabetes and Digestive and Kidney Diseases
dc.relation.grantnoNational Institute on Minority Health and Health Disparities
dc.relation.grantnoNational Institutes of Health, Office of AIDS Research
dc.relation.grantnoUCSF CTSA
dc.relation.grantnoAtlanta Center for AIDS Research [CFAR]
dc.relation.grantnoUniversity of North Carolina CFAR [UL1-TR000004]
dc.relation.grantnoUniversity of Alabama in Birmingham CFAR [P30-AI-050409]
dc.relation.grantno[P30-AI -050410]
dc.relation.grantno[P30 -AI-027767]
dc.sourceAIDS
dc.subjectImmunology
dc.subjectInfectious diseases
dc.subjectVirology
dc.titleThe role of social support on cognitive function among midlife and older adult MSM
dc.typeJournal article
dspace.entity.typePublication
local.contributor.kuauthorTuran, Bülent
relation.isOrgUnitOfPublicationd5fc0361-3a0a-4b96-bf2e-5cd6b2b0b08c
relation.isOrgUnitOfPublication.latestForDiscoveryd5fc0361-3a0a-4b96-bf2e-5cd6b2b0b08c

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