Publication:
Rationally reprogramming single-cell aging trajectories and lifespan through dynamic modulation of environmental inputs

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dc.contributor.coauthorSmart, Matthew
dc.contributor.coauthorMoreno, David F.
dc.contributor.departmentKUTTAM (Koç University Research Center for Translational Medicine)
dc.contributor.departmentSchool of Medicine
dc.contributor.facultymemberYes
dc.contributor.kuauthorAcar, Murat
dc.contributor.schoolcollegeinstituteResearch Center
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-12-29T09:36:48Z
dc.date.issued2024
dc.description.abstractHow do variations in nutrient levels influence cellular lifespan? A dynamical systems model of a core circuit involved in yeast aging suggests principles underlying lifespan extension observed at static and alternating glucose levels that are reminiscent of intermittent fasting regimens.
dc.description.fulltextNo
dc.description.harvestedfromManual
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.openaccessN/A
dc.description.peerreviewstatusPeer-Reviewed
dc.description.publisherscopeInternational
dc.description.readpublishN/A
dc.description.sponsoredbyTubitakEuTÜBİTAK
dc.description.sponsorshipWe thank Hayden Nunley for useful discussions. M.S. acknowledges ongoing support through the Flatiron Institute, a division of the Simons Foundation. D.F.M. acknowledges support by the Fondation ARC pour la recherche sur le cancer. M.A. acknowledges support through the T\u00DCB\u0130TAK 1001 Scientific and Technological Research Projects Funding Program and the Ko\u00E7 University Research Center for Translational Medicine. The authors declare no competing interests.
dc.description.studentonlypublicationNo
dc.description.studentpublicationNo
dc.description.versionN/A
dc.identifier.WoSQuartileQ1
dc.identifier.doi10.1016/j.cels.2024.07.008
dc.identifier.eissn2405-4720
dc.identifier.embargoN/A
dc.identifier.endpage678
dc.identifier.grantnoTUBITAK 1001 Scientific and Technological Research Projects Funding Program
dc.identifier.issn2405-4712
dc.identifier.issue8
dc.identifier.pubmed39173583
dc.identifier.scopus2-s2.0-85201238812
dc.identifier.startpage676
dc.identifier.urihttps://doi.org/10.1016/j.cels.2024.07.008
dc.identifier.urihttps://hdl.handle.net/20.500.14288/22170
dc.identifier.volume15
dc.identifier.wos001300340000001
dc.keywordsLongevity
dc.language.isoeng
dc.publisherCell Press
dc.relation.affiliationKoç University
dc.relation.collectionKoç University Institutional Repository
dc.relation.ispartofCell Systems
dc.relation.openaccessN/A
dc.rightsN/A
dc.subjectBiochemistry and molecular biology
dc.subjectCell biology
dc.titleRationally reprogramming single-cell aging trajectories and lifespan through dynamic modulation of environmental inputs
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorAcar, Murat
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