Publication: Oncogenic mechanisms in renal insufficiency
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KU-Authors
KU Authors
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Volovat, S.R.
Volovat, C.
Miron, I.
Goldsmith, D.
Lungulescu, C.
Badarau, S.C.
Covic A.
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NO
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Abstract
The prevalence of both cancer and end-stage renal disease is increasing. In addition, medical advances have meant increased survival rates for both diseases. Many chemotherapeutics are renally excreted, and conversely, renal insufficiency promotes a pro-neoplastic state, including genitourinary and other cancers. Dialysis prolongs life while increasing cancer risk. Proposed oncogenic mechanisms include immune dysfunction, chronic inflammation, changes in gut microbiota and stimulation of the renin-angiotensin system. This review summarizes current concepts in the relationship between cancer and renal insufficiency.
Source
Publisher
Oxford University Press (OUP)
Subject
Urology and nephrology
Citation
Has Part
Source
Clinical Kidney Journal
Book Series Title
Edition
DOI
10.1093/ckj/sfaa122