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Motor afferents from the cerebellum, zona incerta and substantia nigra to the mediodorsal thalamic nucleus in the rat

dc.contributor.departmentSchool of Medicine
dc.contributor.departmentGraduate School of Health Sciences
dc.contributor.kuauthorAmuk Williams, Özge Ceren
dc.contributor.kuauthorÇavdar, Safiye
dc.contributor.kuauthorÖzgür, Merve
dc.contributor.kuauthorUysal, Sanem Pınar
dc.contributor.schoolcollegeinstituteGRADUATE SCHOOL OF HEALTH SCIENCES
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T23:36:05Z
dc.date.issued2014
dc.description.abstractThe mediodorsal (MD) thalamic nucleus provides information from subcortical structures to the prefrontal cortex. The human MD thalamic nucleus has been implicated in a great variety of different clinical conditions and normal functions ranging from schizophrenia, ParkinsÖnişm and epilepsy to many cognitive functions. In the rat the MD thalamic nucleus is divided into three cytoarchitectonic sectors whereas in the primates it is divided into two; medial one-third (magnocellular) and lateral two-thirds further the lateral sector is divided into pars parvocellularis pars multiformis, pars fasciculosa and pars caudalis. In this study we used a retrograde tracer, fluoro-gold (FG) to evaluate some of the afferents reaching the lateral sector of the MD (MDl) thalamic nucleus. The results of the present study have shown that MDl receives afferent connections from the lateral cerebellar nucleus (dentate nucleus), substantia nigra pars reticulata (SNR) and zona incerta (ZI). Subsequent to FG injections into the MDl, labeled cells were observed mainly bilaterally but were sparser on the contralateral side than ipsilaterally from each of the three structures listed. All three afferents showed a topographical organization. The labeled neurons were localized at the dorsomedial aspect of the lateral cerebellar nucleus, the dorsoventral aspect of the SNR and in the dorsal sector of the ZI. The lateral cerebellar nucleus reached the MDl via the superior cerebellar peduncle. No other deep cerebellar nuclei showed labeled cells. There were no labeled cells in the substantia nigra pars compacta (SNC). Although the three regions identified here are recognized as having motor functions, the connections to MD suggest that their outputs also play a role in cognitive or other higher cortical functions.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue4
dc.description.openaccessNO
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume13
dc.identifier.doi10.1142/S0219635214500198
dc.identifier.eissn1757-448X
dc.identifier.issn0219-6352
dc.identifier.scopus2-s2.0-84929576118
dc.identifier.urihttps://doi.org/10.1142/S0219635214500198
dc.identifier.urihttps://hdl.handle.net/20.500.14288/12577
dc.identifier.wos345922300001
dc.keywordsTract tracing
dc.keywordsRetrograde
dc.keywordsCerebellum
dc.keywordsZona incerta
dc.keywordsSubstantia nigra
dc.keywordsMediodorsal thalamic nucleus
dc.keywordsPrefrontal cortex
dc.keywordsPars reticulata
dc.keywordsBasal-ganglia
dc.keywordsNigrothalamic projections
dc.keywordsCerebral-cortex
dc.keywordsRhesus-monkey
dc.keywordsBrain-stem
dc.keywordsNerve-cell
dc.keywordsOrganization
dc.keywordsConnections
dc.language.isoeng
dc.publisherImr Press
dc.relation.ispartofJournal Of Integrative Neuroscience
dc.subjectNeurosciences
dc.titleMotor afferents from the cerebellum, zona incerta and substantia nigra to the mediodorsal thalamic nucleus in the rat
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorÇavdar, Safiye
local.contributor.kuauthorÖzgür, Merve
local.contributor.kuauthorUysal, Sanem Pınar
local.contributor.kuauthorAmuk Williams, Özge Ceren
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit1GRADUATE SCHOOL OF HEALTH SCIENCES
local.publication.orgunit2School of Medicine
local.publication.orgunit2Graduate School of Health Sciences
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