Publication:
An update review of intradialytic hypotension: concept, risk factors, clinical implications and management

dc.contributor.coauthorAfşar, Barış
dc.contributor.coauthorÖzdoğan, Elif
dc.contributor.coauthorSiriopol, Dimitrie
dc.contributor.coauthorCovic, Adrian
dc.contributor.coauthorBasile, Carlo
dc.contributor.coauthorOrtiz, Alberto
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorErtuğlu, Lale Aslıhan
dc.contributor.kuauthorKanbay, Mehmet
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T23:20:40Z
dc.date.issued2020
dc.description.abstractIntradialytic hypotension (IDH) is a frequent and serious complication of chronic haemodialysis, linked to adverse long-term outcomes including increased cardiovascular and all-cause mortality. IDH is the end result of the interaction between ultrafiltration rate (UFR), cardiac output and arteriolar tone. Thus excessive ultrafiltration may decrease the cardiac output, especially when compensatory mechanisms (heart rate, myocardial contractility, vascular tone and splanchnic flow shifts) fail to be optimally recruited. The repeated disruption of end-organ perfusion in IDH may lead to various adverse clinical outcomes affecting the heart, central nervous system, kidney and gastrointestinal system. Potential interventions to decrease the incidence or severity of IDH include optimization of the dialysis prescription (cool dialysate, UFR, sodium profiling and high-flux haemofiltration), interventions during the dialysis session (midodrine, mannitol, food intake, intradialytic exercise and intermittent pneumatic compression of the lower limbs) and interventions in the interdialysis period (lower interdialytic weight gain and blood pressure-lowering drugs). However, the evidence base for many of these interventions is thin and optimal prevention and management of IDH awaits further clinical investigation. Developing a consensus definition of IDH will facilitate clinical research. We review the most recent findings on risk factors, pathophysiology and management of IDH and, based on this, we call for a new consensus definition of IDH based on clinical outcomes and define a roadmap for IDH research.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue6
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.volume13
dc.identifier.doi10.1093/CKJ/SFAA078
dc.identifier.issn2048-8505
dc.identifier.scopus2-s2.0-85100902596
dc.identifier.urihttps://doi.org/10.1093/CKJ/SFAA078
dc.identifier.urihttps://hdl.handle.net/20.500.14288/10762
dc.identifier.wos608400700008
dc.keywordsCardiovascular event
dc.keywordsHaemodialysis
dc.keywordsIntradialytic hypotension
dc.keywordsRoadmap
dc.keywordsUltrafiltration antihypertensive agent
dc.keywordsCarnitine
dc.keywordsMidodrine
dc.keywordsSodium
dc.keywordsConsensus development
dc.keywordsExercise
dc.keywordsFood intake
dc.keywordsHeart output
dc.keywordsHemodialysis
dc.keywordsHemofiltration
dc.keywordsHuman
dc.keywordsHypotension
dc.keywordsIntradialytic hypotension
dc.keywordsPathophysiology
dc.keywordsPriority journal
dc.keywordsReview
dc.keywordsRisk factor
dc.keywordsUltrafiltration
dc.language.isoeng
dc.publisherOxford University Press
dc.relation.ispartofClinical Kidney Journal
dc.subjectUrology
dc.subjectNephrology
dc.titleAn update review of intradialytic hypotension: concept, risk factors, clinical implications and management
dc.typeReview
dspace.entity.typePublication
local.contributor.kuauthorKanbay, Mehmet
local.contributor.kuauthorErtuğlu, Lale Aslıhan
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
relation.isOrgUnitOfPublicationd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isOrgUnitOfPublication.latestForDiscoveryd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

Files