Publication: Long non-coding RNAs and accelerated aging in bipolar disorder
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Ekinci, S.
Arat Çelik, H.E.
Squassina, A.
Date
Language
eng
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No
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Abstract
Bipolar disorder (BD) has been associated with accelerated biological aging, potentially driven by genetic and environmental factors. Long non-coding RNAs (lncRNAs), key regulators of epigenetic, telomere attrition, and cellular aging processes, may play a role in accelerated aging in BD. This review summarizes current evidence on aging-associated lncRNAs and their relevance to BD. We searched PubMed for English-language original studies published up to June 2, 2025, using keywords related to lncRNAs, aging-related mechanisms, and agingassociated neuropsychiatric disorders. A total of 112 articles reported 163 lncRNAs, of which 19 were common to aging-related mechanisms and aging-associated neuropsychiatric disorders. Among these, ANRIL, HOTAIR, TUG1, MALAT1, NEAT1, and GAS5 have been reported in both aging-related contexts and BD; however, their relevance to BD requires further confirmation in independent and well-characterized cohorts. The remaining overlapping lncRNAs may represent additional candidates of interest for future investigation rather than established contributors to BD pathophysiology.
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Elsevier
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Citation
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Source
Neuroscience Applied
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DOI
10.1016/j.nsa.2026.106990
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CC BY-NC-ND (Attribution-NonCommercial-NoDerivs)
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Creative Commons license
Except where otherwise noted, this item's license is described as CC BY-NC-ND (Attribution-NonCommercial-NoDerivs)