Publication: Long non-coding RNAs and accelerated aging in bipolar disorder
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KU-Authors
KU Authors
Co-Authors
Ekinci, S.
Arat Ćelik, H.E.
Squassina, A.
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Compiler & Affiliation
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Date
Language
eng
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No
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Abstract
Bipolar disorder (BD) has been associated with accelerated biological aging, potentially driven by genetic and environmental factors. Long non-coding RNAs (lncRNAs), key regulators of epigenetic, telomere attrition, and cellular aging processes, may play a role in accelerated aging in BD. This review summarizes current evidence on aging-associated lncRNAs and their relevance to BD. We searched PubMed for English-language original studies published up to June 2, 2025, using keywords related to lncRNAs, aging-related mechanisms, and agingassociated neuropsychiatric disorders. A total of 112 articles reported 163 lncRNAs, of which 19 were common to aging-related mechanisms and aging-associated neuropsychiatric disorders. Among these, ANRIL, HOTAIR, TUG1, MALAT1, NEAT1, and GAS5 have been reported in both aging-related contexts and BD; however, their relevance to BD requires further confirmation in independent and well-characterized cohorts. The remaining overlapping lncRNAs may represent additional candidates of interest for future investigation rather than established contributors to BD pathophysiology.
Source
Publisher
Elsevier
Subject
Neurosciences, Psychiatryv
Citation
Has Part
Source
Neuroscience Applied
Book Series Title
Edition
DOI
10.1016/j.nsa.2026.106990
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Creative Commons license
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