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Influence of multidrug resistant organisms on the outcome of diabetic foot infection

dc.contributor.coauthorSaltoğlu, Neşe
dc.contributor.coauthorTülek, Necla
dc.contributor.coauthorYemisen, Mücahit
dc.contributor.coauthorKadanalı, Ayten
dc.contributor.coauthorKaragöz, Gül
dc.contributor.coauthorBatırel, Ayşe
dc.contributor.coauthorAk, Öznür
dc.contributor.coauthorSönmezer, Cağla
dc.contributor.coauthorEraksoy, Haluk
dc.contributor.coauthorCağatay, Atahan
dc.contributor.coauthorSürme, Serkan
dc.contributor.coauthorNemli, Salih A.
dc.contributor.coauthorDemirdal, Tuna
dc.contributor.coauthorCoşkun, Ömer
dc.contributor.coauthorÖztürk, Derya
dc.contributor.coauthorCeran, Nurgül
dc.contributor.coauthorPehlivanoğlu, Filiz
dc.contributor.coauthorŞengoz, Gönül
dc.contributor.coauthorAslan, Turan
dc.contributor.coauthorAkkoyunlu, Yasemin
dc.contributor.coauthorÖncül, Oral
dc.contributor.coauthorAy, Hakan
dc.contributor.coauthorMülazımoğlu, Lütfiye
dc.contributor.coauthorErtürk, Buket
dc.contributor.coauthorYılmaz, Fatma
dc.contributor.coauthorYörük, Gülşen
dc.contributor.coauthorUzun, Nuray
dc.contributor.coauthorŞimşek, Funda
dc.contributor.coauthorYıldırmak, Taner
dc.contributor.coauthorYaşar, Kadriye Kart
dc.contributor.coauthorSönmezoğlu, Meral
dc.contributor.coauthorKüçükkardalı, Yaşar
dc.contributor.coauthorTuna, Nazan
dc.contributor.coauthorKarabay, Oğuz
dc.contributor.coauthorÖzgüneş, Nail
dc.contributor.coauthorSargın, Fatma
dc.contributor.departmentSchool of Medicine
dc.contributor.kuauthorErgönül, Önder
dc.contributor.schoolcollegeinstituteSCHOOL OF MEDICINE
dc.date.accessioned2024-11-09T13:51:09Z
dc.date.issued2018
dc.description.abstractObjectives: We described the clinical outcomes of the diabetic patients who had foot infections with multidrug resistant organisms. Methods: We included the patients with diabetic foot infections (DFI) from 19 centers, between May 2011 and December 2015. Infection was defined according to IDSA DFI guidelines. Patients with severe infection, complicated moderate infection were hospitalized. The patients were followed-up for 6 months after discharge. Results: In total, 791 patients with DFI were included, 531(67%) were male, median age was 62 (19-90). Severe infection was diagnosed in 85 (11%) patients. Osteomyelitis was diagnosed in 291(36.8%) patients. 536 microorganisms were isolated, the most common microorganisms were S. aureus (20%), P. aeruginosa (19%) and E. coli (12%). Methicillin resistance (MR) rate among Staphylococcus aureus isolates was 31%. Multidrug resistant bacteria were detected in 21% of P. aeruginosa isolates. ESBL (+) Gram negative bacteria (GNB) was detected in 38% of E. coli and Klebsiella isolates. Sixty three patients (8%) were rehospitalized. Of the 791 patiens, 127 (16%) had major amputation, and 24 (3%) patients died. In multivariate analysis, significant predictors for fatality were; dialysis (OR: 8.3, Cl: 1.82-38.15, p = 0.006), isolation of Klebsiella spp. (OR:7.7, Cl: 1.24-47.96, p = 0.028), and chronic heart failure (OR: 3, Cl: 1.01-9.04, p = 0.05). MR Staphylococcus was detected in 21% of the rehospitalized patients, as the most common microorganism (p < 0.001). Conclusion: Among rehospitalized patients, methicillin resistant Staphylococcus infections was detected as the most common agent, and Klebsiella spp. infections were found to be significantly associated with fatality.
dc.description.fulltextYES
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.versionPublisher version
dc.description.volume70
dc.identifier.doi10.1016/j.ijid.2018.02.013
dc.identifier.eissn1878-3511
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR01420
dc.identifier.issn1201-9712
dc.identifier.quartileQ1
dc.identifier.scopus2-s2.0-85044099007
dc.identifier.urihttps://doi.org/10.1016/j.ijid.2018.02.013
dc.identifier.wos432658100002
dc.keywordsDiabetic foot infection
dc.keywordsMRSA
dc.keywordsKlebsiella
dc.keywordsFatality
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofInternational Journal of Infectious Diseases
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/8016
dc.subjectInfectious diseases
dc.titleInfluence of multidrug resistant organisms on the outcome of diabetic foot infection
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorErgönül, Mehmet Önder
local.publication.orgunit1SCHOOL OF MEDICINE
local.publication.orgunit2School of Medicine
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relation.isOrgUnitOfPublication.latestForDiscoveryd02929e1-2a70-44f0-ae17-7819f587bedd
relation.isParentOrgUnitOfPublication17f2dc8e-6e54-4fa8-b5e0-d6415123a93e
relation.isParentOrgUnitOfPublication.latestForDiscovery17f2dc8e-6e54-4fa8-b5e0-d6415123a93e

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