Publication: Towards drugs targeting multiple proteins in a systems biology approach
Program
KU-Authors
KU Authors
Co-Authors
Ma, B.
Nussinov, R.
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Embargo Status
Journal Title
Journal ISSN
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Alternative Title
Ödünç verme hizmetlerinde iPad: Koç Üniversitesi Suna Kıraç Kütüphanesi örneǧi
Abstract
Protein-protein interactions are increasingly becoming drug targets. This is understandable, since they are crucial at all levels of cellular expression and growth. In practice, targeting specific disease-related interactions has proven difficult, with success varying with specific complexes. Here, we take a Systems Biology approach to targeting protein-protein interactions. Below, we first briefly review drug discovery targeted at protein-protein interactions; we classify protein-protein complexes with respect to their types of interactions and their roles in cellular function and as being targets in drug design; we describe the properties of the interfaces as related to drug design, focusing on hot spots and surface cavities; and finally, in particular, we cast the interactions into the cellular network system, highlighting the challenge of partially targeting multiple interactions in the networks as compared to hitting a specific protein-protein interaction target. The challenge we now face is how to pick the targets and how to improve the efficiency of designed partially-specific multi-target drugs that would block parallel pathways in the network.
Source
Publisher
Bentham Science
Subject
Chemistry, Pharmaceutical chemistry
Citation
Has Part
Source
Current Topics in Medicinal Chemistry
Book Series Title
Edition
DOI
10.2174/156802607780906690