Publication:
Towards drugs targeting multiple proteins in a systems biology approach

dc.contributor.coauthorMa, B.
dc.contributor.coauthorNussinov, R.
dc.contributor.departmentDepartment of Chemical and Biological Engineering
dc.contributor.departmentDepartment of Computer Engineering
dc.contributor.kuauthorKeskin, Özlem
dc.contributor.kuauthorGürsoy, Attila
dc.contributor.kuprofileFaculty Member
dc.contributor.kuprofileFaculty Member
dc.contributor.yokid26605
dc.contributor.yokid8745
dc.date.accessioned2024-11-09T23:09:21Z
dc.date.issued2007
dc.description.abstractProtein-protein interactions are increasingly becoming drug targets. This is understandable, since they are crucial at all levels of cellular expression and growth. In practice, targeting specific disease-related interactions has proven difficult, with success varying with specific complexes. Here, we take a Systems Biology approach to targeting protein-protein interactions. Below, we first briefly review drug discovery targeted at protein-protein interactions; we classify protein-protein complexes with respect to their types of interactions and their roles in cellular function and as being targets in drug design; we describe the properties of the interfaces as related to drug design, focusing on hot spots and surface cavities; and finally, in particular, we cast the interactions into the cellular network system, highlighting the challenge of partially targeting multiple interactions in the networks as compared to hitting a specific protein-protein interaction target. The challenge we now face is how to pick the targets and how to improve the efficiency of designed partially-specific multi-target drugs that would block parallel pathways in the network.
dc.description.indexedbyWoS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue10
dc.description.openaccessNO
dc.description.publisherscopeInternational
dc.description.sponsorshipIntramural NIH HHS Funding Source: Medline
dc.description.sponsorshipNCI NIH HHS [N01-CO-12400] Funding Source: Medline
dc.description.volume7
dc.identifier.doi10.2174/156802607780906690
dc.identifier.eissn1873-4294
dc.identifier.issn1568-0266
dc.identifier.quartileQ3
dc.identifier.scopus2-s2.0-34447288741
dc.identifier.urihttp://dx.doi.org/10.2174/156802607780906690
dc.identifier.urihttps://hdl.handle.net/20.500.14288/9272
dc.identifier.wos247773800004
dc.keywordsStructurally conserved residues
dc.keywordsHot-spots
dc.keywordsSmall molecules
dc.keywordsBinding-sites
dc.keywordsReverse-transcriptase
dc.keywordsComputational methods
dc.keywordsDiscovery
dc.keywordsDesign
dc.keywordsInterfaces
dc.keywordsReceptor
dc.languageEnglish
dc.publisherBentham Science
dc.sourceCurrent Topics in Medicinal Chemistry
dc.subjectChemistry
dc.subjectPharmaceutical chemistry
dc.titleTowards drugs targeting multiple proteins in a systems biology approach
dc.title.alternativeÖdünç verme hizmetlerinde iPad: Koç Üniversitesi Suna Kıraç Kütüphanesi örneǧi
dc.typeReview
dspace.entity.typePublication
local.contributor.authorid0000-0002-4202-4049
local.contributor.authorid0000-0002-2297-2113
local.contributor.kuauthorKeskin, Özlem
local.contributor.kuauthorGürsoy, Attila
local.publication.orgunit1College of Engineering
local.publication.orgunit2Department of Chemical and Biological Engineering
local.publication.orgunit2Department of Computer Engineering
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relation.isOrgUnitOfPublication89352e43-bf09-4ef4-82f6-6f9d0174ebae
relation.isOrgUnitOfPublication.latestForDiscovery89352e43-bf09-4ef4-82f6-6f9d0174ebae

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