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In vitro antibacterial and cytotoxicity assessment of magnetron sputtered Ti1.5ZrTa0.5Nb0.5W0.5 refractory high-entropy alloy doped with Ag nanoparticles

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dc.contributor.departmentDepartment of Chemistry
dc.contributor.departmentDepartment of Chemical and Biological Engineering
dc.contributor.departmentGraduate School of Sciences and Engineering
dc.contributor.departmentKUYTAM (Koç University Surface Science and Technology Center)
dc.contributor.kuauthorAcar, Havva Funda Yağcı
dc.contributor.kuauthorAlamdari, Armin Asghari
dc.contributor.kuauthorGüner, Pınar Tatar
dc.contributor.kuauthorHashemkhani, Mahshid
dc.contributor.kuauthorHendessi, Saman
dc.contributor.kuauthorKavaklı, İbrahim Halil
dc.contributor.kuauthorMotallebzadeh, Amir
dc.contributor.kuauthorÜnal, Uğur
dc.contributor.schoolcollegeinstituteCollege of Engineering
dc.contributor.schoolcollegeinstituteCollege of Sciences
dc.contributor.schoolcollegeinstituteGRADUATE SCHOOL OF SCIENCES AND ENGINEERING
dc.contributor.schoolcollegeinstituteResearch Center
dc.date.accessioned2024-11-09T23:09:28Z
dc.date.issued2022
dc.description.abstractThe aim of the current study is to develop and evaluate antibacterial and biocompatible refractory high-entropy alloy (RHEAs) film using RF magnetron sputtering technique. For this purpose, Ti1.5ZrTa0.5Nb0.5W0.5 RHEA film and its Ag nanoparticle doped analog (with an Ag content of 9 atomic %) were deposited on Ti6Al4V substrate. The microstructural characterization revealed the homogenous distribution of the constituent elements and amorphous structure of the deposited films. The antibacterial activity of Ag nanoparticles doped RHEA film was compared with that of undoped film and uncoated Ti6Al4V. The results indicated that doping Ag nanoparticles reduced the colony forming unit of P. Aeruginosa and S. Aureus bacteria by 98.5% and 90.9%, respectively. In addition, healthy C2C12 mouse muscle myoblast cells adhered and proliferated perfectly on the surface of antibacterial Ag nanoparticles doped RHEA film with no indication of toxic effect, demonstrating promising biocompatibility in addition to its strong antibacterial property.
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.openaccessNO
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuTÜBİTAK
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TÜBİTAK)
dc.description.volume203
dc.identifier.doi10.1016/j.vacuum.2022.111286
dc.identifier.eissn1879-2715
dc.identifier.issn0042-207X
dc.identifier.quartileQ2
dc.identifier.scopus2-s2.0-85132848258
dc.identifier.urihttps://doi.org/10.1016/j.vacuum.2022.111286
dc.identifier.urihttps://hdl.handle.net/20.500.14288/9308
dc.identifier.wos824143700001
dc.keywordsRefractory high-entropy alloys
dc.keywordsAg nanoparticles
dc.keywordsMagnetron sputtering
dc.keywordsAntibacterial
dc.language.isoeng
dc.publisherElsevier
dc.relation.grantno119R010
dc.relation.ispartofVacuum
dc.subjectMaterials science, multidisciplinary
dc.subjectPhysics, applied
dc.titleIn vitro antibacterial and cytotoxicity assessment of magnetron sputtered Ti1.5ZrTa0.5Nb0.5W0.5 refractory high-entropy alloy doped with Ag nanoparticles
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorAlamdari, Armin Asghari
local.contributor.kuauthorHashemkhani, Mahshid
local.contributor.kuauthorHendessi, Saman
local.contributor.kuauthorGüner, Pınar Tatar
local.contributor.kuauthorAcar, Havva Funda Yağcı
local.contributor.kuauthorKavaklı, İbrahim Halil
local.contributor.kuauthorÜnal, Uğur
local.contributor.kuauthorMotallebzadeh, Amir
local.publication.orgunit1GRADUATE SCHOOL OF SCIENCES AND ENGINEERING
local.publication.orgunit1College of Sciences
local.publication.orgunit1College of Engineering
local.publication.orgunit1Research Center
local.publication.orgunit2Department of Chemistry
local.publication.orgunit2Department of Chemical and Biological Engineering
local.publication.orgunit2KUYTAM (Koç University Surface Science and Technology Center)
local.publication.orgunit2Graduate School of Sciences and Engineering
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