Publication:
Optimal euploid embryo transfer strategy, fresh versus frozen, after preimplantation genetic screening with next generation sequencing: a randomized controlled trial

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SCHOOL OF MEDICINE
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Coates, Alison
Kung, Allen
Mounts, Emily
Hesla, John
Bankowski, Brandon
Barbieri, Elizabeth
Cohen, Jacques
Munne, Santiago

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Objective: To compare two commonly used protocols (fresh vs. vitrified) used to transfer euploid blastocysts after IVF with preimplantation genetic screening. Design: Randomized controlled trial. Setting: Private assisted reproduction center. Patient(s): A total of 179 patients undergoing IVF treatment using preimplantation genetic screening. Intervention(s): Patients were randomized at the time of hCG administration to either a freeze-all cycle or a fresh day 6 ET during the stimulated cycle. Main Outcome Measure(s): Implantation rates (sac/embryo transferred), ongoing pregnancy rates (PRs) (beyond 8 weeks), and live birth rate per ET in the primary transfer cycle. Result(s): Implantation rate per embryo transferred showed an improvement in the frozen group compared with the fresh group, but not significantly (75% vs. 67%). The ongoing PR (80% vs. 61%) and live birth rates (77% vs. 59%) were significantly higher in the frozen group compared with the fresh group. Conclusion(s): Either treatment protocol investigated in the present study can be a reasonable option for patients. Freezing all embryos allows for inclusion of all blastocysts in the cohort of embryos available for transfer, which also results in a higher proportion of patients reaching ET. These findings suggest a trend toward favoring the freeze-all option as a preferred transfer strategy when using known euploid embryos.

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Elsevier

Subject

Obstetrics, Gynecology, Reproductive biology

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Fertility and Sterility

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DOI

10.1016/.fertnstert.2016.12.022

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