Publication:
Potential of serum and urinary matrix metalloproteinase-9 levels for the early detection of renal involvement in children with henoch-schonlein purpura

dc.contributor.coauthorErol, Meltem
dc.contributor.coauthorYiğit, Özgül
dc.contributor.coauthorGayret, Özlem Bostan
dc.contributor.coauthorBüke, Övgü
dc.contributor.coauthorGüneş, Ayşegül
dc.contributor.coauthorHamilçıkan, Şahin
dc.contributor.coauthorKasapçopur, Özgür
dc.contributor.departmentKUH (Koç University Hospital)
dc.contributor.kuauthorTaşdemir, Mehmet
dc.contributor.schoolcollegeinstituteKUH (KOÇ UNIVERSITY HOSPITAL)
dc.date.accessioned2024-11-09T12:31:41Z
dc.date.issued2016
dc.description.abstractBackground: Matrix metalloproteinase-9 (MMP-9) is an enzyme implicated in the pathogenesis of renal diseases. Renal involvement is the principal cause of morbidity and mortality in children with Henoch-Schonlein purpura (HSP). Objectives: The aim of this study was to evaluate whether serum and urinary MMP-9 levels are associated with renal involvement in HSP Patients and Methods: We evaluated 40 children with HSP (patient group) and 27 healthy volunteer children (control group). The patient group was divided into two subgroups based on the presence or absence of nephritis. Nephritis was defined as the existence of hematuria and/or proteinuria. All anthropometric data, physical examination findings, blood pressure, and laboratory parameters were recorded. The serum and urine samples were analyzed to determine the MMP-9 levels three days after the initial phase of the disease. Results: The mean age was 7.65 +/- 3.41 (range 2-16) years in the patient group and 9.52 +/- 3.91 (range 2-16) years in the control group. Henoch-Schonlein purpura nephritis (HSPN) was identified in eight patients. There was no significant difference in the serum MMP-9 levels between the HSPN subgroup and the controls (P > 0.05). However, there were significant differences in the urinary MMP-9 levels between the HSP subgroup and the control group (P < 0.05), with the urinary MMP-9 levels being significantly higher in patients in the HSP subgroup (P = 0.001). Further, the urinary MMP-9 levels were significantly higher in the patients with nephritis than in the patients without nephritis (P = 0.001) and the controls (P = 0.001). The optimal cut-off point (sensitivity; specificity) of the urinary MMP-9 level for the diagnosis of HSPN was 94.7 pg/mL. Conclusions: The levels of MMP-9 in the urine were remarkably high in patients with HSPN. This non-invasive marker may the refore be an important indicator for the early diagnosis of nephritis in children with HSP.
dc.description.fulltextYES
dc.description.indexedbyWOS
dc.description.indexedbyScopus
dc.description.indexedbyPubMed
dc.description.issue4
dc.description.openaccessYES
dc.description.publisherscopeInternational
dc.description.sponsoredbyTubitakEuN/A
dc.description.sponsorshipEducational Planning Coordination Committee Of Bagcilar Training And Research Hospital
dc.description.versionPublisher version
dc.description.volume26
dc.identifier.doi10.5812/ijp.6129
dc.identifier.eissn2008-2150
dc.identifier.embargoNO
dc.identifier.filenameinventorynoIR00924
dc.identifier.issn2008-2142
dc.identifier.quartileQ4
dc.identifier.scopus2-s2.0-84987933731
dc.identifier.urihttps://hdl.handle.net/20.500.14288/1948
dc.identifier.wos384932700018
dc.keywordsHenoch-Schonlein purpura
dc.keywordsHenoch-Schonlein purpura nephritis
dc.keywordsMatrix metalloproteinase-9
dc.language.isoeng
dc.publisherKowsar Publishing Corporation
dc.relation.ispartofIranian Journal of Pediatrics
dc.relation.urihttp://cdm21054.contentdm.oclc.org/cdm/ref/collection/IR/id/927
dc.subjectMedicine
dc.subjectPediatrics
dc.subjectPediatric nephology
dc.titlePotential of serum and urinary matrix metalloproteinase-9 levels for the early detection of renal involvement in children with henoch-schonlein purpura
dc.typeJournal Article
dspace.entity.typePublication
local.contributor.kuauthorTaşdemir, Mehmet
local.publication.orgunit1KUH (KOÇ UNIVERSITY HOSPITAL)
local.publication.orgunit2KUH (Koç University Hospital)
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relation.isParentOrgUnitOfPublication055775c9-9efe-43ec-814f-f6d771fa6dee
relation.isParentOrgUnitOfPublication.latestForDiscovery055775c9-9efe-43ec-814f-f6d771fa6dee

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