Research Outputs

Permanent URI for this communityhttps://hdl.handle.net/20.500.14288/2

Browse

Filters

Advanced Search

Filter by

Settings

Indexed at: search.filters.indexed.N/ASponsors: search.filters.sponsors.N/A

Search Results

Now showing 1 - 10 of 65
  • Thumbnail Image
    PublicationOpen Access
    3D-printed contact lenses: challenges towards translation and commercialization
    (Future Medicine, 2022) Yetişen, Ali K.; Department of Mechanical Engineering; Taşoğlu, Savaş; Özdalgıç, Berin; Faculty Member; PhD Student; Department of Mechanical Engineering; KU Arçelik Research Center for Creative Industries (KUAR) / KU Arçelik Yaratıcı Endüstriler Uygulama ve Araştırma Merkezi (KUAR); Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); College of Engineering; Graduate School of Sciences and Engineering; 291971; 323683
    NA
  • Thumbnail Image
    PublicationOpen Access
    A case of radiologically isolated syndrome developing Balo's concentric sclerosis lesions on long-term follow-up
    (Elsevier, 2022) Danyeli, Ayça Ersen; Altıntaş, Ayşe; Çalışkan, İlay; Peker, Selçuk; Faculty Member; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; Graduate School of Health Sciences; Koç University Hospital; 11611; N/A; N/A; 11480
    Background; Radiologically Isolated Syndrome (RIS) depicts a clinical scenario with multiple sclerosis (MS)-like magnetic resonance imaging (MRI) findings in individuals without clinical features of a demyelinating bout. Balo’s concentric sclerosis (BCS) on the other hand, is a variant of MS characterized by concentrically layered white mater demyelinating lesions. Case presentation: a 49-year-old male with an incidental brain lesion on MRI underwent a stereotactic biopsy and diagnosed as a demyelinating process. He remained asymptomatic throughout the long term clinical and radiological follow-up. However, the patient developed new demyelinating lesions with some showing concentric layers of BCS. Conclusion:this is the first reported case; to our knowledge, whereby a pathologically verified RIS patient developed characteristic BCS lesions. Our case highlights the heterogeneity of RIS as a clinico-radiological entity, requiring further sub-classification of the spectrum for improved management
  • Thumbnail Image
    PublicationOpen Access
    A community-based approach to prevention of pressure injuries: a study of the European Wound Management Association Research Grant
    (European Wound Management Association (EWMA), 2021) Karadağ, Ayişe; Çakar, Vildan; Faculty Member; School of Medicine; Graduate School of Health Sciences; 3549; N/A
    Pressure injuries (PIs) are important health problems all over the world because of their serious effects. Awareness of PIs and their effects has increased in recent years. Since patients’ relatives are part of the care team, they have an important role to play in the prevention of PIs. The most crucial aspect of the prevention of PIs is the education of healthcare professionals, patients and patients’ relatives and caregivers. This study aimed to educate caregivers on the prevention of PIs through the development of a digital game. With this purpose, we developed and used a technological education approach —a digital game— that employs gamification methods
  • Thumbnail Image
    PublicationOpen Access
    A critical approach to the biocompatibility testing of NiTi orthodontic archwires
    (Vibgyor Online Publishers, 2016) Şahbazoğlu, D.; Toker, S. M.; Saher, D.; Department of Mechanical Engineering; Canadinç, Demircan; Gümüş, Berkay; Uzer, Benay; Yıldırım, Cansu; Polat-Altıntaş, Sevgi; Faculty Member; Department of Mechanical Engineering; College of Engineering; 23433; N/A; N/A; N/A; N/A
    The biocompatibility of Nickel-Titanium (NiTi) archwires was investigated by simulating actual contact state of archwires around brackets, which enabled incorporation of realistic mechanical conditions into ex situ experiments. Specifically, archwires (undeformed, and bound to brackets on acrylic dental molds) were statically immersed in artificial saliva (AS) for 31 days. Following the immersion, the archwires and the immersion solutions were analyzed with the aid of variouselectron-optical techniques, and it was observed that carbon-rich corrosion products formed on both archwire sets upon immersion. The corrosion products preferentially formed at the archwire–bracket contact zones, which is promoted by the high energy of these regions and the micro-cracks brought about by stress assisted corrosion. Moreover, it is suggested that these corrosion products prevented significant Ni or Ti ion release by blocking the micro-cracks, which, otherwise, would have led to enhanced ion release during immersion. The current findings demonstrate the need for incorporating both realistic chemical and mechanical conditions into the ex situ biocompatibility experiments of orthodontic archwires, including the archwire-bracket contact.
  • Thumbnail Image
    PublicationOpen Access
    A note on weakly compact homomorphisms between uniform algebras
    (Polish Academy of Sciences, 1997) Department of Mathematics; Ülger, Ali; Faculty Member; Department of Mathematics; College of Sciences
  • Thumbnail Image
    PublicationOpen Access
    Algeria’s manufacturing sector: few avenues to diversification
    (The Lebanese Center for Policy Studies, 2017) Bustos, Sebastian; Department of Economics; Yıldırım, Muhammed Ali; Faculty Member; Department of Economics; College of Administrative Sciences and Economics; 219280
    This policy report on Algeria’s industrial sector is the eighth in a series of reports aimed at identifying strategic options Arab countries have in undertaking structural transformation. Using the product space methodology, this report analyzes existing capabilities of selected economies by identifying products they currently export and determining which path they should follow to produce more sophisticated and strategic products. Algeria’s position in the product space suggests that the country’s future path for development should focus on new opportunities in the chemical and food clusters. Redeploying productive knowledge that already exists within the country into other more complex products would prove difficult but the current position implies that, unaided, the economy is unlikely to diversify. This suggests the need to adopt proactive industrial policies entailing a number of new industries or products at which to target public inputs.
  • Thumbnail Image
    PublicationOpen Access
    An empirical investigation of four well-known polynomial-size VRP formulations
    (NA, 2018) Öncan, Temel; Department of Business Administration; N/A; Aksen, Deniz; Sadatizamanabad, Mirehsan Hesam; Faculty Member; Department of Business Administration; College of Administrative Sciences and Economics; Graduate School of Sciences and Engineering; 40308; N/A
    This study presents an in-depth computational analysis of four well-known Capacitated Vehicle Routing Problem (CVRP) formulations with polynomial number of subtour elimination constraints: a node-based formulation and three arc-based (single, two- and multi-commodity flow) formulations. For each formulation, several valid inequalities (VIs) are added for the purpose of tightening the formulation. Moreover, a simple topology-driven granulation scheme is proposed to reduce the number of a certain type of VIs. The lower and upper bounding performance and the solution efficiency of the formulations and respective VI configurations are benchmarked with state-of-the-art commercial optimization software. The extensive computational analysis embraces 121 instances with up to 100 customer nodes. We believe that our findings could be useful for practitioners as well as researchers developing algorithms for the CVRP.
  • Thumbnail Image
    PublicationOpen Access
    An historical geographic information system for Ottoman Studies. The c. 1907 Ottoman Census and Armenian Settlement in Istanbul
    (Peeters Online Journals, 2020) Ohanian, Daniel; Başkurt, Z. Mehmet; Department of History; Kabadayı, Mustafa Erdem; Faculty Member; Department of History; College of Social Sciences and Humanities; 33267
    The purpose of this article is to announce the publication of a partial transcription of the c. 1907 Ottoman census that relates to 24,000 Apostolic Armenian Istanbulites and of a historical geographic information system (HGIS), or interactive map, that shows where these individuals lived. Within this framework, the authors first present their argument that an unidentified, microfilmed population register housed in New York is the most substantial portion of this census currently available to researchers. In the second part of their article, they introduce HGISes as tools for the digital humanities and describe the process of creating one.
  • Thumbnail Image
    PublicationOpen Access
    An improved lower bound on the competitive ratio of deterministic online algorithms for the multi-agent k-Canadian Traveler Problem
    (Finding Press, 2022) Shiri, Davood; Department of Industrial Engineering; Salman, Fatma Sibel; Faculty Member; Department of Industrial Engineering; College of Engineering; 178838
    We present an improved lower bound on the competitive ratio of deterministic online algorithms for the multi-agent k-Canadian Traveler Problem.
  • Thumbnail Image
    PublicationOpen Access
    Arab country product space report introduction and methodology
    (The Lebanese Center for Policy Studies, 2017) Bustos, Sebastian; Department of Economics; Yıldırım, Muhammed Ali; Faculty Member; Department of Economics; College of Administrative Sciences and Economics; 219280
    During the decades prior to the Arab spring, Arab countries on average had one of the lowest per capita growth rates compared to other parts of the world. Although countries in the region registered higher growth rates at the beginning of the century, this economic growth did not bring about a structural transformation required to diversify Arab economies. The challenge remains not only in how to ensure these economies grow but also to ensure that growth is inclusive and sustainable. The general objective of the report is to lay out the strategic options Arab countries have in undertaking structural transformation. Using the product space methodology, the existing capabilities of selected economies are analyzed by locating products they currently export, which assists in determining which path they should follow to produce more sophisticated and strategic products.