Researcher:
Ercan, Alaattin Cenk

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Doctor

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Alaattin Cenk

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Ercan

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Ercan, Alaattin Cenk

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2018 - 20205

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Researcher Of Publications: search.filters.isAuthorOfPublication.31c80897-1442-42fb-a31e-dc679557035d

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    Validity and reliability of the Turkish version of Snaith-Hamilton pleasure scale
    (Association for Cognitive and Behavioral Psychotherapies, 2020) Aydemir, Ömer; N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; Eser, Hale Yapıcı; Yalçınay-İnan, Merve; Küçüker, Mehmet Utku; Kılçıksız, Can Mişel; Yılmaz, Sezen Güçlü; Dinçer, Neris; Kılıç, Özge; Ercan, Alaattin Cenk; Faculty Member; Doctor; Researcher; Researcher; Undergraduate Student; Undergraduate Student; Doctor; Doctor; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; N/A; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; N/A; Koç University Hospital; 134359; N/A; N/A; N/A; N/A; 349025; N/A; N/A
    Anhedonia is a core feature of many psychiatric disorders and its reliable evaluation is needed for the dimensional understanding of psychiatric disorders. Snaith-Hamilton Pleasure Scale (SHAPS) is one of the most widely used scales to assess anhedonia. Here, we aimed to search the validity and reliability of the Turkish version of SHAPS. Translation of the original scale was completed in a two-step procedure. 188 healthy controls, 56 patients with a depressive disorder (F32-F34, excluding F34.0 cyclothymic disorder, according to ICD-10), and 52 patients with anxiety, stress-related or somatoform disorder diagnoses (F40-49 diagnosis according to ICD-10) were recruited, and evaluated with the Turkish version of SHAPS, Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI) and Symptom Checklist-90-R (SCL-90-R). For the Turkish version of SHAPS, Cronbach’s alpha coefficient was found 0.87. The item-total item correlation indices ranged from 0.39 to 0.64. Principal components analysis extracted two factors and explained 46.57 % of total variance. The most significant correlation of SHAPS was found with BDI and depression subscale of SCL-90-R scores. SHAPS also weakly but significantly correlated with obsessive compulsive and anxiety subscales of SCL-90-R, and weakly but non-significantly with BAI and somatization, interpersonal sensitivity, hostility and psychoticism subscales of SCL-90-R. Depressive group had significantly higher SHAPS scores compared to controls and anxious group. Anxious group and control group were not significantly different for SHAPS scores. The current study shows that the Turkish version of the SHAPS has good psychometric properties. SHAPS scores may correlate with depression, somatization, and interpersonal sensitivity scores, and it may help to differentiate depressive patients from anxious patients and controls. /Öz: Anhedoni, birçok psikiyatrik bozukluğun temel bir özelliğidir ve psikiyatrik bozuklukların boyutsal olarak anlaşılması için güvenilir bir şekilde değerlendirilmesi gerekir. Snaith-Hamilton Keyif Alma Ölçeği (SHKÖ), anhedoniyi değerlendirmek için en yaygın kullanılan ölçeklerden biridir. Burada, SHKÖ’nün Türkçe versiyonunun geçerliliği ve güvenilirliğinin araştırılması amaçlanmıştır. Orijinal ölçeğin çevirisi iki aşamalı bir prosedürle tamamlanmıştır. 188 sağlıklı kontrol, 56 depresif bozukluk (ICD-10’a göre F34.0 (siklotimi) dışında F32-F34 tanıları almış kişiler) ve 52 anksiyete, stres ilişkili veya somatoform bozukluk tanısı almış olan anksiyöz hasta (ICD-10’a göre F40-49 tanıları almış kişiler) çalışmaya alınmıştır. Katılımcılar SHKÖ’nün Türkçe versiyonu, Beck Depresyon Envanteri (BDE), Beck Anksiyete Envanteri (BAE) ve Belirti Kontrol Listesi-90-Gözden Geçirilmiş Form (SCL-90-R) ile değerlendirilmiştir. SHKÖ’nün Türkçe versiyonu için Cronbach alfa katsayısı 0,87 olarak bulunmuştur. Madde-toplam madde korelasyon endeksleri 0,39 ile 0,64 arasında değişmiştir. Temel bileşenler analizi iki faktörü ortaya çıkarmış ve toplam varyansın % 46,57‘ sini açıklamıştır. En yüksek SHKÖ korelasyonu BDE ve SCL-90-R‘nin depresyon alt ölçeği skorları ile bulunmuştur. SHKÖ ayrıca SCL-90-R‘nin obsesif kompulsif ve anksiyete alt ölçekleri ile zayıf fakat istatiksel olarak anlamlı bir korelasyon gösterirken, SCL-90- R‘nin somatizasyon, kişilerarası duyarlılık, hostilite ve psikotisizm alt ölçekleri ile zayıf fakat istatistiksel olarak anlamlı olmayan bir ilişki göstermiştir. Depresif hasta grubunda kontrol grubuna ve anksiyöz hasta grubuna göre anlamlı derecede yüksek SHKÖ skorları saptanmıştır. Anksiyöz hasta grubu ve kontrol grubu, SHKÖ skorları için farklı bulunmamıştır. Bu çalışma, SHKÖ’nün Türkçe versiyonunun iyi psikometrik özellikleri olduğunu göstermektedir. SHKÖ puanları depresyon, somatizasyon ve kişilerarası duyarlılık puanları ile ilişkili olabilir ve depresif hastaları anksiyöz hastalardan ve kontrollerden ayırmada yardımcı olabilir.
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    PublicationMetadata only
    Development, validity and reliability of the 4-point likert Turkish version of cognitive failures questionnaire
    (İnönü Üniversitesi Tıp Fakültesi, 2020) Aydemir, Ömer; N/A; Eser, Hale Yapıcı; Yalçınay-İnan, Merve; Küçüker, Mehmet Utku; Kılçıksız, Can Mişel; Yılmaz, Sezen Güçlü; Dinçer, Neris; Kılıç, Özge; Ercan, Alaattin Cenk; Faculty Member; Doctor; Researcher; Researcher; Undergraduate Student; Undergraduate Student; Doctor; Doctor; School of Medicine; N/A; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; N/A; Koç University Hospital; 134359; N/A; N/A; N/A; N/A; 349025; N/A; N/A
    Aim: Cognitive failures are suggested to be a transdiagnostic endophenotype that increases the vulnerability for psychiatric disorders. Broadbent’s Cognitive Failures Questionnaire (CFQ), is among the most widely used scales to assess cognitive function observed in an ecological manner. Despite its wide use in research and correlation with biological markers, CFQ is criticized for its unstable factorial structure among studies and 5-Likert structure that may lead to bias for neutral answers. Here we aimed to develop a 4-Likert Turkish version of CFQ, search its validity, reliability and factorial structure. Material and Methods: CFQ has been translated to Turkish in two steps. CFQ, Perceived Deficit Questionnaire-D (PDQ-D), Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) were applied to 272 participants (187 healthy controls, 55 patients diagnosed with depression, 30 patients diagnosed with anxiety disorder). Results: The Cronbach’s alpha coefficient of 4-Likert Turkish version of CFQ was found as 0.91. Principal component analysis extracted five factors and explained 53.7 % of total variance. CFQ scores were significantly different among groups. Both depressive and anxious groups reported higher CFQ scores compared to controls. CFQ significantly and strongly correlated with PDQ-D and showed a moderate correlation with BDI and BAI. Conclusion: 4-Likert Turkish version of CFQ is a valid and reliable tool to assess cognitive failures in non-demented groups. Our analysis revealed a five factorial structure for CFQ, however previous literature with the 5-Likert version shows different factor structures and does not indicate a dimensional stability.
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    Subjective cognitive assessments and n-back are not correlated, and they are differentially affected by anxiety and depression
    Kılıç, Özge; Aydemir, Ömer; Eser, Hale Yapıcı; Yalçınay-İnan, Merve; Küçüker, Mehmet Utku; Kılçıksız, Can Mişel; Yılmaz, Sezen Güçlü; Dinçer, Neris; Ercan, Alaattin Cenk; Faculty Member; Doctor; Researcher; Researcher; Undergraduate Student; Undergraduate Student; Doctor; School of Medicine; Koç University Hospital; 134359; N/A; N/A; N/A; 349025; N/A
    Cognitive function (CF) is a core feature related to all psychiatric disorders. However, self-report scales of CF (SRSC) may not always correlate with CF’s objective measures and may have different mediators. Tools to select for evaluating CF in diverse psychiatric populations and their determinants need to be studied. In this study, we aimed to assess the association of SRSC (Perceived Deficit Questionnaire-Depression (PDQ-D), and World Health Organization’s Adult Attention Deficit Hyperactivity Disorder Self-Report Scale (ASRS) and its inattentiveness subscale) with Letter-N-back as an objective measure of CF, and to analyze their association with psychopathology. Two hundred nine (131 nonclinical, and 78 clinical with a psychiatric diagnosis of ICD10 F31-39 [mood disorders excluding Bipolar I] or F40-F49 [neurotic, stress-related or psychosomatic disorder] categories) participants were evaluated with PDQ-D, ASRS, Beck Depression Inventory (BDI), and Beck’s Anxiety Inventory (BAI), and N-back. Both groups’ data were included in the analysis. PDQ-D showed a small correlation with N-back scores, whereas ASRS showed no correlation. PDQ-D and ASRS showed a large correlation. Age and BAI scores significantly predicted both PDQ-D and ASRS, whereas the cognitive subscale of BDI predicted PDQ-D, but not ASRS. Only BAI scores predicted N-back results. The mediation model revealed that 2-back scores of N-back task directly affects PDQ-D scores, independent of BDI scores. However, the cognitive subscale of BDI moderated 2-back and PDQ-D association. On the contrary, BAI scores significantly mediated the association of 2-back scores with PDQ-D. The direct effect of 2-back scores in PDQ-D was insignificant in the mediation of BAI scores. Our study validates the discordance between SRSC and an objective measurement of CF. Anxiety may affect both self-report and objective measurement of CF, whereas depressive thought content may lead to higher cognitive dysfunction reports in nondemented participants.
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    Impacts of psychotic disorders outpatient unit on the hospitalization rate, duration and the indirect costs
    (Elsevier France-Editions Scientifiques Medicales Elsevier, 2018) Cenker, O. C.; Varlik, D. Sarikaya; Tatar, Z. Baran; Yesilyurt, S. Lapcin; N/A; Ercan, Alaattin Cenk; Doctor; N/A; Koç University Hospital; N/A
    N/A
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    PublicationOpen Access
    The place of optical coherence tomography in patients with obsessive compulsive disorder
    (Aves, 2019) Polat, Selim; Gediz, Berrak Şekeryapan; Kaim, Muhammet; Hocaoğlu, Çicek; Ercan, Alaattin Cenk; PhD Student; Koç University Hospital
    Objective: optical coherence tomography (OCT) is an increasingly used new method that investigates changes in the retinal nerve fiber layer (RNFL) in neurodegenerative diseases. It provides high-resolution cross-sectional imaging of biological tissues. This study aimed to investigate the structural changes in RNFL in patients with obsessive compulsive disorder (OCD) using OCT and to investigate the possible effects of retinal function on the etiopathogenesis of OCD. Materials and Methods: in this study, 30 patients diagnosed with OCD at the end of the Structured Clinical Interview for DSM (SCID-I), without any drug use status, and 31 healthy participants paired with the patients in terms of their sociodemographic characteristics were included. In the patient and control groups, the RNFL thickness was measured and compared at each locus using OCT. Results: statistically significant differences were found in RNFL, ganglion cell layer thickness, and central foveal thickness between the patients with OCD and the control group. In this study, the choroidal thickness values of the patient group were found to be higher than those of the control group; and a statistically significant difference was observed in the mean choroidal thickness values (p=0.045). Conclusion: the findings of the study suggest that the RNFL thickness of patients with OCD does not decrease, but choroidal thickness may be an important biomarker to determine the etiopathogenesis of the disease and follow neurodegeneration.
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    PublicationOpen Access
    Can visual hallucinations be among the neuropsychological manifestations of systemic mastocytosis?: a geriatric case
    (Aves, 2020) Çetiner, Mustafa; Kılıç, Özge; Ercan, Alaattin Cenk; Komesli, Zeynep; Yılmaz, Uğur Eser; Doctor; School of Medicine; Koç University Hospital
    Mast cells are considered sensors of environmental and emotional stress, exist in all body parts and are related to the pathway from stress to inflammation. Mastocytosis defines a rare disease characterized by the accumulation of abnormal mast cells in multiple organs. Here, we present a 77-year-old woman with a background of aggressive systemic mastocytosis who developed impaired cognition, depression, anxiety, visual hallucinations, delusions, and insomnia. Symptoms alleviated only after initiating midostaurin, a tyrosine kinase inhibitor. Systemic mastocytosis should be kept in mind when visual hallucinations are concomitant with chronic or recurrent multi-system disturbances and do not benefit from treatment as usual.