Researcher:
Karahan, Salih Nafiz

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Researcher

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Salih Nafiz

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Karahan

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Karahan, Salih Nafiz

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2018 - 201932020 - 20225

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Now showing 1 - 8 of 8
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    Robotic liver resection: recent developments
    (Springer, 2020) Kose, Emin; Berber, Eren; N/A; Karahan, Salih Nafiz; Researcher; School of Medicine; 337050
    Purpose of Review The popularity of robotic liver surgery has vastly increased in the last decade with the aim to overcome the disadvantages of laparoscopic liver surgery using inherent advantages of robotic technology including improved dexterity, enhanced range of motion and better vision. The purpose of this review is to assess the current literature on robotic liver resection and present its perioperative outcomes, oncologic outcomes, learning curve, cost effectiveness and limitations. Recent Findings Several articles have been published on different aspects of robotic liver resection in the recent years. High cost associated with robotic equipment is a major drawback, however, decreased perioperative morbidity and lower costs reported in recent articles hints a trend towards acceptable cost. In terms of perioperative outcomes, robotic liver resection was reported to be superior to open liver resection and comparable to laparoscopic liver resection. Regarding oncologic outcomes, robotic liver resection was found to be equal compared to open and laparoscopic resection.
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    Single-incision robotic adrenalectomy (SIRA): the future of adrenal surgery?
    (Ame Publishing Company, 2020) Ağcaoğlu, Orhan; Tezelman, Tevfik Serdar; Karahan, Salih Nafiz; Tüfekçi, Tutku; Faculty Member; Faculty Member; Researcher; Researcher; School of Medicine; School of Medicine; School of Medicine; School of Medicine; 175476; 114860; 337050; 327608
    In compliance with the trend toward less invasive techniques, single incision robotic surgeries have become more common and they have been increasingly used for several surgeries including adrenalectomy. Single incision robotic adrenalectomy (SIRA) aims to combine the merits of robotic surgery with previously defined single incision laparoscopic techniques. It has been shown to be safe and feasible, however, there are only few studies on this new technique. Due to scant data on SIRA in the current literature, it remains to be a current challenge in adrenal surgery. In this review, our goal is to present current literature on SIRA and discuss the data regarding perioperative outcomes, patient selection, learning curve, and its limitations.
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    A new technique in treatment of Zenker diverticulum: submucosal tunneling endoscopic septum division (Z-POEM) versus classic endoscopic septomyotomy techniques
    (Mosby-Elsevier, 2019) N/A; Aslan, Fatih; Yılmaz, Onur; Şengün, Berke; Ünlükaplan, Aytekin; Karahan, Salih Nafiz; Koçak, Elif; Faculty Member; Undergraduate Student; Undergraduate Student; Doctor; Researcher; Undergraduate Student; School of Medicine; School of Medicine; School of Medicine; N/A; School of Medicine; School of Medicine; Koç University Hospital; 219202; N/A; 309087; N/A; 337050; N/A
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    Per-oral endoscopic myotomy (poem) in the treatment of achalasia; clinical outcomes of 430 patients, single center study
    (Mosby-Elsevier, 2019) N/A; Aslan, Fatih; Karahan, Salih Nafiz; Yılmaz, Onur; Şengün, Berke; Koçak, Elif; Darçın, Kamil; Faculty Member; Researcher; Undergraduate Student; Undergraduate Student; Undergraduate Student; Teaching Faculty; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; 219202; 337050; N/A; 309087; N/A; 203217
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    PublicationOpen Access
    The use of focused, radioguided parathyroidectomy in geriatric patients with a history of thyroid surgery
    (Hellenic Society of Nuclear Medicine, 2020) Falay, Fikri Okan; Ağcaoğlu, Orhan; Karahan, Salih Nafiz; Deniz, Sinan; Gökler, Ozan; Aydemir, Yeliz; Taşkın, Orhun Çığ; Tezelman, Tevfik Serdar; Demirkol, Mehmet Onur; Teaching Faculty; Faculty Member; Researcher; Doctor; Teaching Faculty; Faculty Member; Faculty Member; Faculty Member; School of Medicine; Koç University Hospital; 246484; 175476; N/A; N/A; 311179; N/A; 166686; N/A; 196946
    Objective: geriatric patients are often reluctant to undergo parathyroid surgery under general anesthesia because of the major comorbidities. The use of minimally invasive techniques for parathyroid lesions under local anesthesia have been published. Radioguided lesion localization has been known to decrease operative time and reduce the occurrence of positive margins in breast cancer surgery. We hypothesize that it could also be effectively used in focused parathyroid surgery in geriatric patients with in history of thyroid surgery. Materials and methods: our study group consists of geriatric patients with a history of thyroid surgery who underwent focused parathyroid surgery between February 2017 and October 2019. Group-1 included 18 patients who had parathyroidectomy under radioguidance. Group-2, 22 patients who had surgery without it. Patient demographics, operative time, number of frozen sections and length of hospital stay were analyzed. Results: analyzed data were similar between groups. The mean age of the patients was 72.56±12.65 years (range: 65-88). The operative times for group-1 and group-2, were 65.42±7.78 and 74.63±15.98 minutes, respectively (P=0.002). All patients were discharged uneventfully on postoperative day-2. Conclusion: radioguidance parathyroidectomy positively affected the operative time and also decreased the need for additional frozen section.
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    PublicationOpen Access
    The role of tissue inhibitor of metalloproteinases in the aetiology of inguinal and incisional hernias
    (Wiley, 2022) Düzköylü, Yiğit; Paşaoğlu, Esra; Aren, Acar; Durukan, Uğur; Ağcaoğlu, Orhan; Özoran, Emre; Karahan, Salih Nafiz; Özata, İbrahim Halil; Faculty Member; Teaching Faculty; Researcher; Graduate School of Health Sciences; School of Medicine; N/A; 175476; 307296; N/A; N/A
    Inguinal and incisional hernias are the two most common types of hernias caused by abdominal wall weakness and defects in connective tissue. The structure of the extracellular matrix, mainly collagen and metalloproteinases (MMPs), and their regulators have been studied extensively and found to play a significant role in the pathophysiology of hernias. One of the regulators of MMPs, tissue inhibitor metalloproteinases (TIMPs), bind to MMPs and inhibit its activity significantly shifting the balance towards collagen synthesis rather than degradation. Due to their importance in collagen metabolism, their metabolism might be significant in the aetiology of hernias. Our study used immunohistochemical techniques to investigate the possible effects of TIMP 1 and 2 on the samples taken from the abdominal walls of patients with inguinal and incisional hernias, compared them with control patients, and reviewed the literature. In this study, samples of 90 patients (30 patients from control, inguinal hernia, and incisional hernia groups) were taken and analysed. These samples were stained with TIMP-1 Ab-2 and TIMP2 Ab-5 (Clone 3A4) antibodies and evaluated under x100 magnification. The degree of staining was classified as (a): No staining (0), (b): Staining less than 10% (I), (c): Staining between 10% and 50% (II), (d): Staining more than 50% (III). Statistical analyses were done. No significant difference was found between groups in terms of patient demographics. Smoking and family history of hernia was not found to be associated with TIMP expression. TIMP1 expression was significantly higher in the incisional and inguinal hernia group than in the control group (P < .05), while the level of TIMP2 was higher in the control group. (P < .05). TIMP1 and TIMP2 levels did not significantly differ between incisional and inguinal hernia groups. We found significantly increased TIMP-1 levels in tissue samples from patients with hernia supporting its suggested role in hernia pathophysiology. Local alterations in MMP and TIMP levels might play a role in the pathogenesis of hernias. Thus detection of TIMP in tissues can be important for clinical use after further validation studies. In the era of molecular medicine, detecting TIMP levels in hernia patients can impact clinical practice.
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    PublicationOpen Access
    Ascorbic acid: a promising agent in chronic kidney disease?
    (Oxford University Press (OUP), 2018) Afşar, Barış; Kanbay, Mehmet; Karahan, Salih Nafiz; Faculty Member; School of Medicine; 110580; N/A
    Asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, is related with impaired endothelial function and poor outcomes in chronic kidney disease (CKD) patients. In addition, oxidative stress and inflammation are also a common problemin CKD patients, and both have an important role in the development and progression of atherosclerosis and increased cardiovascular events in CKD. Ascorbic acid might be a promising agent in CKD for improving outcome by decreasing oxidative stress and ADMA levels.
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    PublicationOpen Access
    Single-incision robotic adrenalectomy (SIRA): the future of adrenal surgery?
    (AME Publishing Company, 2020) Ağcaoğlu, Orhan; Karahan, Salih Nafiz; Tüfekçi, Tutku; Tezelman, Tevfik Serdar; Faculty Member; Researcher; Researcher; School of Medicine; 175476; N/A; N/A; N/A
    In compliance with the trend toward less invasive techniques, single incision robotic surgeries have become more common and they have been increasingly used for several surgeries including adrenalectomy. Single incision robotic adrenalectomy (SIRA) aims to combine the merits of robotic surgery with previously defined single incision laparoscopic techniques. It has been shown to be safe and feasible, however, there are only few studies on this new technique. Due to scant data on SIRA in the current literature, it remains to be a current challenge in adrenal surgery. In this review, our goal is to present current literature on SIRA and discuss the data regarding perioperative outcomes, patient selection, learning curve, and its limitations.