Researcher:
Doran, Tansu

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PhD Student

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Tansu

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Doran

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Doran, Tansu

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2021 - 20224

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Researcher Of Publications: search.filters.isAuthorOfPublication.7d6d76ab-c4cc-4aab-bdf5-a9f5a4b8f51c

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    Frequency of myelin oligodendrocyte glycoprotein antibodies in pediatric onset multiple sclerosis
    (2022) Solmaz, İsmail; Konuşkan, Bahadır; Öncel, İbrahim; Anlar, Banu; Doran, Tansu; Yousefi, Mohammadreza; Vural, Atay; PhD Student; PhD Student; Faculty Member; Graduate School of Health Sciences; Graduate School of Health Sciences; School of Medicine; Koç University Hospital; N/A; N/A; 182369
    Background: Myelin oligodendrocyte glycoprotein antibodies (MOG-Ab) are associated with acute demyelinating syndromes and only rarely detected in multiple sclerosis (MS). As MOG-Ab associated disease is common in childhood, we speculated young patients might be more likely to produce MOG-Ab and investigated the frequency of MOG-Ab seropositivity in pediatric onset MS (POMS).Material and methods: Patients who experienced their first acute demyelinating event before age 18 years and were diagnosed with MS during follow-up were included in this single-center study. Patient data were retrieved from clinical records. Serum samples obtained and frozen at clinical visits were analyzed for MOG-Ab by a live cell-based assay (CBA) measuring delta mean fluorescence intensity (MFI) and MFI ratio. The control group consisted of patients referred to pediatric neurology for headache or vertigo and who had no neurological dis-order (n = 48). Another control group consisted of patients with systemic inflammatory disorders systemic lupus erythematosus (n = 17) and juvenile idiopathic arthritis (n = 13) diagnosed in the rheumatology clinic.Results: The patient group (n 1/4 122, F/M: 90/32, mean age 17.8 & PLUSMN; 2.6 years) were initially diagnosed as: MS, 62/122 (50.8%), clinically isolated syndrome, 43/122 (35.2%), radiologically isolated syndrome, 9/122 (7.3%), and acute disseminated encephalomyelitis 8/122 (6.5%). All received the final diagnosis of POMS. Serum was sampled 22.4 & PLUSMN; 29.2 (0-132) months after the first episode. None of the control groups had MOG-Ab positivity while 2/122 (1.6%) POMS cases had MOG-Abs, and a third patient had positive MFI and a MFI ratio slightly below the cut-off. These three patients' initial and final diagnoses were MS, their annualized relapsing rates (ARRs) were 0.4-0.6, and most recent Expanded Disability Status Scale was 0.Conclusion: Low titers of MOG-Ab can be detected in a small number of POMS patients at similar frequency with adult MS. Our POMS cases with MOG-Abs presented brainstem-cerebellar findings or seizures and had low ARR. Further series and longer follow-up will define whether these cases differ significantly from MOG-Ab negative POMS cases.
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    Novel CD20+innate lymphoid cells show increased killing capacity and are related to multiple sclerosis prognosis
    (Sage Publications Ltd, 2022) Üzülmez, M.; Baytekin, I.; Esendağlı, G.; Meinl, I.; Köseoğlu, M.; Yüksel, B.; Soysal, A.; Meinl, E.; N/A; Albayrak, Özgür; Doran, Tansu; Kızılırmak, Ali Burak; Soylu, Kemal; Erdem, Haluk; Researcher; PhD Student; PhD Student; Other; Other; N/A; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); N/A; Graduate School of Health Sciences; Graduate School of Health Sciences; N/A; N/A; N/A; N/A; N/A; N/A
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    Myelin oligodendrocyte glycoprotein antibodies in genetic leukodystrophies
    (Elsevier, 2022) Eroğlu Ertuğrul, Nesibe Gevher; Pekgüzel, Faruk; Guenbey, Ceren; Topçu, Meral; Oğuz, Kader K.; Özkara, Hatice Asuman; Anlar, Banu; N/A; N/A; Yousefi, Mohammadreza; Doran, Tansu; Vural, Atay; PhD Student; PhD Student; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); N/A; N/A; N/A; Graduate School of Health Sciences; School of Medicine; N/A; N/A; 182369
    Accumulation of intermediate metabolites due to enzyme deficiencies and demyelination can provoke inflammation in genetic leukodystrophies. Thirty patients with genetic leukodystrophy and 48 healthy control sera were tested for anti-myelin oligodendrocyte glycoprotein (MOG) antibodies by fixed and/or live cell-based assays. MOG-IgG was detected in two late infantile metachromatic leukodystrophy (MLD) cases, both of which were also weakly positive for IgG1, and one with IgG3 as the dominant anti-MOG IgG subclass. MOG-IgG was borderline positive in a vanishing white matter (VWM) disease patient. These results suggest that inherited metabolic or degenerative processes can have an autoimmune component, possibly as an epiphenomenon.
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    Functional properties of CD56+CD20 natural killer cells and their relationship with demyelinating disorders
    (Sage Publications Ltd, 2021) Kizilirmak, A. B.; Uzulmez, M.; Baytekin, I.; Soylu, K.; Esendagli, G.; Meinl, I.; Koseoglu, M.; Yuksel, B.; Soysal, A.; Mainl, E.; Vural, A.; N/A; N/A; N/A; N/A; N/A; Albayrak, Özgür; Doran, Tansu; Kızılırmak, Ali Burak; Kolsuz, Selin; Erdem, Halil Eren; Researcher; PhD Student; PhD Student; Teaching Faculty; Undergraduate Student; Undergraduate Student; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); N/A; Graduate School of Health Sciences; Graduate School of Health Sciences; School of Medicine; School of Medicine; N/A; N/A; N/A; English Language Center; N/A; N/A; N/A; N/A; N/A; N/A
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