Researcher:
Ülkü, İrem

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Undergraduate Student

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İrem

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Ülkü

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Ülkü, İrem

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2018 - 20202

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Researcher Of Publications: search.filters.isAuthorOfPublication.95000866-0440-446a-beac-69c1874d12a4

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    Homogenous photopolymerization of acrylic monomers initiated with ZnO-methacrylate in non-aqueous medium and production of luminescent nanocomposites
    (Royal Society Chemistry, 2018) Morlet-Savary, Fabrice; Lalevee, Jacques; Department of Chemistry; Department of Chemistry; Ülkü, İrem; Acar, Havva Funda Yağcı; Undergraduate Student; Faculty Member; Department of Chemistry; Koç University Surface Science and Technology Center (KUYTAM) / Koç Üniversitesi Yüzey Teknolojileri Araştırmaları Merkezi (KUYTAM); College of Sciences; College of Sciences; N/A; 178902
    Luminescent ZnO/methacrylic acid was demonstrated as an active photoinitiator in the free radical polymerization of vinyl monomers in bulk and in organic solvent without a protic solvent or a co-catalyst, producing luminescent nanocomposites for the first time. Excitation between 320 and 390 nm provided the best results but PEGDA was also successfully initiated at 400-500 nm.
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    Etoposide loaded SPION-PNIPAM nanoparticles improve thein vitrotherapeutic outcome on metastatic prostate cancer cells via enhanced apoptosis
    (Wiley-V C H Verlag Gmbh, 2020) Erkısa, Merve; Arı, Ferda; Ulukaya, Engin; Department of Chemistry; Department of Chemistry; N/A; Department of Chemistry; Ülkü, İrem; Khodadust, Rouhollah; Yar, Yasemin; Acar, Havva Funda Yağcı; Undergraduate Student; Other; PhD Student; Faculty Member; Department of Chemistry; College of Sciences; College of Sciences; Graduate School of Sciences and Engineering; College of Sciences; N/A; N/A; N/A; 178902
    Prostate cancer is among the leading causes of death worldwide because its metastatic form is a deadly disease. Therefore, the development of new chemotherapeutics is of immense importance. Nanoparticle technology seems to provide diverse options in this regard. Therefore, poly(N-isopropylacrylamide) (PNIPAM) coated superparamagnetic iron oxide nanoparticles (SPION) loaded with Etoposide were prepared in small sizes (57 nm) and with 3.5 % drug content to improve the efficiency of Etoposide in prostate cancer therapy. Sustained release of the drug was achieved, which found to be sensitive to low pH and high temperature. The anti-growth activity of SPION-PNIPAM-Etoposide formulation against metastatic prostate cancer cells (PC-3, LNCaP) were investigated by SRB assay, then, confirmed by ATP assay. Mode of cell death was evaluated by using flow cytometry analyses. A significant improvement of nanoformulated drug was observed at 5-10 mu g/ml doses of the drug in both cell lines. More importantly, this formulation enhanced the cytotoxic effect of Etoposide on PC-3 cells, which is considered more resistant to Etoposide than LNCaP and reduced the IC(50)value by 55 % reaching to 4.5 mu g drug/ml, which is a very significant improvement in the literature. It was clearly shown that nanoformulated drug provided about 3-fold increases in caspase-dependent early apoptotic cells in PC-3 cells. The novel formulation seems to successfully cause cell death of especially PC-3 metastatic prostate cancer cells. It should therefore be taken into consideration for further animal studies as a novel potent anticancer agent.