Researcher:
Güneyli, Serkan

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Doctor

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Serkan

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Güneyli

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Güneyli, Serkan

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2020 - 202210

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    Cystic renal diseases: role of ultrasound. part II, genetic cystic renal diseases
    (Societatea Romana de Ultrasonografie in Medicina si Biologie, 2022) Gunduz, Nesrin; Keven, Ayse; Durmaz, Emel; Aslan, Mine; Güneyli, Serkan; Kabaalioğlu, Adnan; Faculty Member; Doctor; School of Medicine; School of Medicine; 36622; N/A
    Kidney cysts are quite common in adults. Though small simple renal cysts in an adult over 30-40 years of age are not too unusual, however, if the same cysts are seen in a child, and especially if there are additional findings, then several diagnostic possibilities may come to mind. The role of ultrasound, together with the help of intravenous contrast agents and Doppler mode, are very critical in describing the morphologic features and follow-up of the complex or multiple and bilateral renal cysts. These sonographic signs are occasionally specific for diagnosis, but in many cases sonographic clues should be evaluated together with the other genetic and clinical data to reach diagnosis. The first part of this pictorial essay included the introduction into the subject and the classification of non-genetic cystic renal diseases. The key features for the non-genetic cystic renal diseases are illustrated. In the second part, eye-catching features of genetic cystic renal diseases are demonstrated. © 2022 Societatea Romana de Ultrasonografie in Medicina si Biologie. All rights reserved.
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    Incidentally detected perineal aggressive angiomyxoma in an asymptomatic patient with uterine leiomyomas
    (Taylor & Francis Inc, 2021) Temur, Muzaffer; N/A; Altınmakas, Emre; Doğan, Hakan; Güneyli, Serkan; Other; Researcher; Faculty Member; School of Medicine; School of Medicine; School of Medicine; 143682; 327614; 36622
    N/A
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    PublicationMetadata only
    Intrathyroidal ectopic thymus and sonoelastographic findings
    (Bentham Science Publ Ltd, 2021) Sağtaş, Ergin; Çolakoğlu, Bülent; Güneyli, Serkan; Aygün, Murat Serhat; Taşkın, Orhun Çığ; Faculty Member; Teaching Faculty; Faculty Member; School of Medicine; School of Medicine; School of Medicine; 36622; 291692; 166686
    Background: Intrathyroidal ectopic thymus (IET) can be misdiagnosed as thyroid nod-ules. Purpose: The purpose of this study is to evaluate the sonoelastographic findings of IET in pediatric population. Methods: Twelve children who had been examined with ultrasound (US) and strain elastography between December 2012 and December 2019 were included in this retrospective study. The pa-tients' demographics and ultrasonographic findings, including the location, margin, shape, diame-ters, volume, structure, vascularity, and elastography values of the lesions were evaluated. Results: Twelve lesions were detected in 12 asymptomatic patients (3 females and 9 males) with a mean age of 4.67 +/- 2.27 years. The most common location of the IET was in posterior part and mid-dle third of thyroid, and the most common appearance on US was a well-defined, ovoid-shaped, and predominantly hypoechoic solid lesion with punctate/linear branching hyperechogenities. The lesions were mostly hypovascular on Doppler US. The mean strain ratio on elastography was found to be 1.10 +/- 0.04. In the follow-up of 7 patients with available information, there was no sig-nificant change in size or appearance of IET on US. Conclusion: IET should be considered in the differential diagnosis of the lesions within the thy-roid. The first step to accurately diagnose an IET is to consider it in the differential diagnosis. In ad-dition to US, strain elastography findings can be used to distinguish IETs from papillary thyroid cancers which can have similar US appearance, and help avoid unnecessary biopsies.
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    Multiparametric mri evaluation of developmental venous anomalies in the brain: association with signal changes on flair in patients with multiple sclerosis
    (Bentham Science Publ Ltd, 2020) Sağtaş, Ergin; Akyılmaz, Dinçer Aydın; Yavaş, Hüseyin Gökhan; Çakmak, Pınar; Ufuk, Furkan; N/A; Güneyli, Serkan; Faculty Member; School of Medicine; Koç University Hospital; 36622
    Background: Developmental venous anomalies (DVAs) can be determined on magnetic resonance imaging (MRI), and they may be associated with multiple sclerosis (MS) lesions. Purpose: The objective was to evaluate the MRI findings of DVAs in the brain, to compare the prevalence of them between MS patients and control subjects, and to investigate the correlation of DVA-associated fluid-attenuated inversion recovery (FLAIR) hyperintensities and MRI-derived parameters between MS patients and control subjects having DVA. Methods: Total 160 patients with a mean age of 45 +/- 16 years who underwent multiparametric MRI including susceptibility-weighted imaging (SWI), diffusion-weighted imaging, 3D FLAIR, and contrast-enhanced imaging were included in this retrospective study. First, the presence of DVA was compared between the MS and control groups using the Chi-square test. Then, among the subjects having DVA, age, gender, and MRI-derived parameters such as the signal increase of DVA on FLAIR, location, and drainage of DVA were compared between the MS and control groups using Chi-square test. Results: The presence of DVA did not differ between the MS and control groups (P = 0.828). Signal increase around DVA on FLAIR (P = 0.03) and the age of less than 45 years demonstrated a significant correlation with MS group (P = 0.022). Conclusion: In our study, DVAs were effectively detected using SWI and 3D contrast-enhanced T-1-weighted imaging on MRI. The signal increase of DVA was better revealed on 3D FLAIR on MRI, and it was the only significant MRI-derived parameter in patients with MS.
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    PublicationOpen Access
    An intrathyroidal nodule consisting of papillary thyroid cancer and ectopic hyperechoic parathyroid adenoma: a case report
    (Iuliu Hatieganu Medical Publishing House, 2021) Altınmakas, Emre; Güneyli, Serkan; Kabaalioğlu, Adnan; Çil, Barbaros Erhan; Samadli, Vugar; Doğan, Hakan; Taşkın, Orhun Çığ; Özışık, Seçil; Ağcaoğlu, Orhan; Faculty Member; Researcher; Faculty Member; Doctor; Faculty Member; School of Medicine; Koç University Hospital; N/A; N/A; 169993; N/A; 327614; 166686; N/A; 175476
    A 53-year-old woman with fatigue lasting for 6 weeks and increased parathormone level underwent a neck ultrasound. It revealed a large, lobulated, solid intrathyroidal nodule consisting of hypoechoic component with microcalcifications and hy-perechoic component with vascularity on Doppler mode. There were also subcentimetric intrathyroidal hypo- and hyperechoic nodules. Upon the diagnosis of papillary thyroid cancer on fine-needle aspiration biopsy, a total thyroidectomy procedure was performed. In the histopathologic evaluation, the hypoechoic component was diagnosed as papillary thyroid cancer, while the hyperechoic component was diagnosed as ectopic parathyroid adenoma. Subcentimetric nodules were demonstrated as multi-foci of papillary thyroid cancer.
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    PublicationOpen Access
    Spin-echo and diffusion-weighted MRI in differentiation between progressive massive fibrosis and lung cancer
    (Aves, 2021) Tor, Meltem; Hassoy, Hür; Altıntaş, Susamber Dik; Savaş, Recep; Güneyli, Serkan; Aygün, Murat Serhat; Altınmakas, Emre; Teaching Faculty; Other; School of Medicine; Koç University Hospital; N/A; 291692; 143682
    Purpose: we aimed to investigate the value of magnetic resonance imaging (MRI)- based parameters in differentiating between progressive massive fibrosis (PMF) and lung cancer. Methods: this retrospective study included 60 male patients (mean age, 67.0 +/- 9.0 years) with a history of more than 10 years working in underground coal mines who underwent 1.5 T MRI of thorax due to a lung nodule/mass suspicious for lung cancer on computed tomography. Thirty patients had PMF, and the remaining ones had lung cancer diagnosed histopathologically. The sequences were as follows: coronal single-shot turbo spin echo (SSH-TSE), axial T1- and T2-weighted spin-echo (SE), balanced turbo field echo, T1-weighted high- resolution isotropic volume excitation, free-breathing and respiratory triggered diffusion-weighted imaging (DWI). The patients' demographics, lesion sizes, and MRI-derived parameters were compared between the patients with PMF and lung cancer. Results: Apparent diffusion coefficient (ADC) values of DWI and respiratory triggered DWI, signal intensities on T1-weighted SE, T2-weighted SE, and SSH-TSE imaging were found to be significantly different between the groups (p < 0.001, for all comparisons). Median ADC values of free-breathing DWI in patients with PMF and cancer were 1.25 (0.93-2.60) and 0.76 (0.53-1.00) (x 10(-3) mm(2)/s), respectively. Most PMF lesions were predominantly iso- or hypointense on T1- weighted SE, T2-weighted SE, and SSH-TSE, while most malignant ones predominantly showed high signal intensity on these sequences. Conclusion: MRI study including SE imaging, specially T1-weighted SE imaging and ADC values of DWI can help to distinguish PMF from lung cancer.
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    PublicationOpen Access
    Determinants of pancreatic steatosis: a retrospective observational study
    (Iranian Association of Gastroenterology and Hepatology, 2021) Siriopol, Dimitrie; Sag, Alan A.; Afşar, Barış; Covic, Adrian; Johnson, Richard J.; Altınmakas, Emre; Şentürk, Begüm Güler; Çöpür, Sidar; Güneyli, Serkan; Doğan, Hakan; Balık, Emre; Kanbay, Mehmet; Other; Researcher; Researcher; Researcher; Faculty Member; Faculty Member; School of Medicine; N/A; 327593; 368625; 36622; 327614; 18758; 110580
    Backgroud: metabolic syndrome affects 35% of the adult population in developed countries associated with non-alcoholic steatohepatitis, insulin resistance, and cardiovascular events. Fatty infiltration of the pancreas, or pancreatic steatosis, is a risk factor for acute pancreatitis, pancreatic malignancies, and diabetes mellitus, yet its relationship with metabolic syndrome is not well defined. Methods: we performed a single-centered retrospective observational study of 322 healthy subjects (subjects volunteering to be kidney transplant donors, mean age=46.3±13.5, 163 men and 159 women) in the last 2 years (July 2018-February 2020) from our institution. Pancreatic steatosis and hepatosteatosis were confirmed by computed tomography. Results: pancreatic steatosis was present in 26.3% (85/322) of the subjects, and this finding correlated with age, body mass index (BMI), male sex, a family history of diabetes, creatinine, cystatin C, uric acid, low-density lipoprotein (LDL) cholesterol, triglycerides, glycemia, hemoglobin, transverse body diameter, and subcutaneous fat thickness levels by univariable logistic regression. On multiple linear regression only age (95% CI 1.01, 1.06), BMI (95% CI 1.01, 1.19), male sex (95% CI 1.49-5.99), uric acid (95% CI 1.01, 1.76), and subcutaneous fat thickness levels (95% CI 1.21-2.36) remained independently associated with pancreatic steatosis. Conclusion: pancreatic steatosis is common and associated with obesity, elevated serum uric acid, subcutaneous fat thickness, and male sex. Future studies are needed to evaluate if there are specific clinical consequences to the presence of pancreatic steatosis.
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    PublicationOpen Access
    Cystic renal diseases: role of ultrasound. Part II, genetic cystic renal diseases
    (Romanian Society for Ultrasonography in Medicine and Biology (SRUMB), 2022) Gündüz, Nesrin; Keven, Ayşe; Durmaz, Emel; Aslan, Mine; Aslan, Ahmet; Kabaalioğlu, Adnan; Güneyli, Serkan; Koç University Hospital
    Kidney cysts are quite common in adults. Though small simple renal cysts in an adult over 30-40 years of age are not too unusual, however, if the same cysts are seen in a child, and especially if there are additional findings, then several diagnostic possibilities may come to mind. The role of ultrasound, together with the help of intravenous contrast agents and Doppler mode, are very critical in describing the morphologic features and follow-up of the complex or multiple and bilateral renal cysts. These sonographic signs are occasionally specific for diagnosis, but in many cases sonographic clues should be evalu-ated together with the other genetic and clinical data to reach diagnosis. The first part of this pictorial essay included the introduction into the subject and the classification of non-genetic cystic renal diseases. The key features for the non-genetic cystic renal diseases are illustrated. In the second part, eye-catching fea-tures of genetic cystic renal diseases are demonstrated.
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    PublicationOpen Access
    Cystic renal diseases: role of ultrasound. Part I, non-genetic cystic renal diseases
    (Iuliu Hatieganu Medical Publishing House, 2021) Gündüz, Nesrin; Keven, Ayşe; Durmaz, Emel; Aslan, Mine; Aslan, Ahmet; Kabaalioğlu, Adnan; Güneyli, Serkan; Koç University Hospital
    Kidney cysts are quite common in adults. Though small simple renal cysts in an adult over 30-40 years of age are not too unusual, however, if the same cysts are seen in a child, and especially if there are additional findings, then several diagnostic possibilities may come to mind. The role of ultrasound, together with the help of intravenous contrast agents and Doppler mode, is very critical in describing the morphologic features and follow-up of the complex or multiple and bilateral renal cysts. Sonographic signs are occasionally specific for diagnosis, but in many cases they should be evaluated together with the other genetic and clinical data to reach a diagnosis. The first part of this pictorial essay includes ""non-genetic cystic renal diseases"" and the second part will include ""genetic cystic renal diseases"".
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    PublicationOpen Access
    Radiological approach to COVID-19 pneumonia with an emphasis on chest CT
    (Aves, 2020) Güneyli, Serkan; Atçeken, Zeynep; Doğan, Hakan; Altınmakas, Emre; Atasoy, Kayhan Çetin; Doctor; Researcher; Other; Faculty Member; School of Medicine
    Coronavirus disease 2019 (COVID-19) has recently become a worldwide outbreak with several millions of people infected and more than 160.000 deaths. A fast and accurate diagnosis in this outbreak is critical to isolate and treat patients. Radiology plays an important role in the diagnosis and management of the patients. Among various imaging modalities, chest CT has received attention with its higher sensitivity and specificity rates. Shortcomings of the real-time reverse transcriptase-polymerase chain reaction test, including inappropriate sample collection and analysis methods, initial false negative results, and limited availability has led to widespread use of chest CT in the diagnostic algorithm. This review summarizes the role of radiology in COVID-19 pneumonia, diagnostic accuracy of imaging, and chest CT findings of the disease.