Researcher:
Alagöl, Faruk

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Doctor

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Faruk

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Alagöl

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Alagöl, Faruk

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2018 - 201912020 - 20214

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    Effect of prophylactic central neck dissection on the surgical outcomes in papillary thyroid cancer: experience in a single center
    (Springer, 2020) Colakoglu, Bulent; Aydin, Ozlem; Terzioglu, Tarik; Dereli, Dilek Yazıcı; Sezer, Havva; Alagöl, Faruk; Kurtoğlu, Burçin Sağlam; Kapran, Yersu; Demirkol, Mehmet Onur; Faculty Member; Teaching Faculty; Doctor; Teaching Faculty; Faculty Member; Faculty Member; School of Medicine; School of Medicine; N/A; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; 179659; 154807; N/A; 172911; 168101; 196946
    Purpose: Morbidity due to papillary thyroid carcinoma (PTC) is increased mostly due to lymph node (LN) metastases, which lead to reoperations and complications associated with these operations. The aim is to compare the outcomes of PTC having total thyroidectomy and prophylactic central lymph node dissection (TT + PCND) with patients having total thyroidectomy (TT) alone. Methods: This study is a retrospective cohort analysis of 358 PTC patients that were operated by a single surgeon in a single center. Data about the patients were extracted from the medical records. Results: Of the patient cohort, 258 patients had TT + PCND (42.5 ± 11.3 years) and 100 patients (41.2 ± 11.9 years) had only TT. Total number of LN extracted in the TT + PCND group was 8.1 ± 6.9. The mean number of metastatic LN were 2.2 ± 1.9. Percentage of patients that had RAI were less in the TT + PCND group compared to the TT group. Seven patients (2.7%) in the TT + PCND group and 19 (19.0%) in TT group had recurrent disease (p < 0.0001). Of the complications, only transient hypoparathyroidism was increased in TT + PCND group compared to TT group (26.7% vs 10%, p < 0.0001). Conclusion: TT + PCND performed by an experienced surgeon seems to decrease the number of LN recurrences, and the need for reoperations.
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    Concomittant occurence of well-differentiated thyroid carcinoma metastasis and chronic lymphocytic leukemia in the same lymph node along with internal jugular vein thrombus: a case report
    (Wolters Kluwer Medknow Publications, 2021) Tezelman, Serdar; Peker, Önder; Çolakoğlu, Bülent; Ferhanoğlu, Burhan T; Sezer, Havva; Dereli, Dilek Yazıcı; Demirkol, Mehmet Onur; Ünal, Ömer Faruk; Dilege, Şükrü; Taşkın, Orhun Çığ; Kapran, Yersu; Aygün, Murat Serhat; Alagöl, Faruk; Teaching Faculty; Faculty Member; Faculty Member; Other; Faculty Member; Faculty Member; Faculty Member; Teaching Faculty; Doctor; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; American Hospital; American Hospital; American Hospital; American Hospital; 154807; 179659; 196946; 199800; 122573; 166686; 168101; 291692; N/A
    Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is the most common adult leukemia. The coexistence of CLL and papillary thyroid carcinoma (PTC) is extremely rare. PTC sometimes shows microscopic vascular invasion but rarely cause a tumor thrombus in the internal jugular vein (IJV). It is also rare to find both differentiated and poorly differentiated types of thyroid cancer in the same metastatic location. We report a case of 63-year-old Turkish man with history of CLL who had CLL/SLL involvement and PTC metastasis in the same lymph node. Additionally, there was macroscopic metastasis to the IJV with poorly differentiated areas in the removed tumor thrombus. Patient was treated with total thyroidectomy, left radical neck dissection, resection of the left IJV segment that contained the tumor thrombus and radioactive iodine (RAI) therapy. Furthermore, metastatic lesions were found in the brain, lung and bone. Radiotherapy and chemotherapy were performed. However, our patient died approximately 12 months after thyroidectomy. To our knowledge, our present report is the first description with its current features.
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    Erdheim-chester disease: case report with testes involvement and review of literature
    (Elsevier Science inc, 2018) N/A; N/A; N/A; N/A; N/A; N/A; N/A; N/A; Sezer, Havva; Aygün, Murat Serhat; Armutlu, Ayşe; Acar, Ömer; Falay, Fikri Okan; Dereli, Dilek Yazıcı; Deyneli, Oğuzhan; Alagöl, Faruk; Teaching Faculty; Teaching Faculty; Teaching Faculty; Faculty Member; Teaching Faculty; Faculty; Faculty Member; Doctor; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; 154807; 291692; 133567; 237530; 246484; 179659; 171914; /N/A
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    PublicationOpen Access
    The clinicopathologic characteristics of familial and sporadic papillary thyroid carcinoma in Turkish patients
    (TÜBİTAK, 2020) Sezer, Havva; Demirkol, Mehmet Onur; Dereli, Dilek Yazıcı; Kapran, Yersu; Alagöl, Faruk; Teaching Faculty; Faculty Member; Faculty Member; Faculty Member; School of Medicine; N/A; 196946; 179659; 168101; N/A
    Background/aim: The aim of this study is to investigate clinicopathologic features of familial papillary thyroid carcinoma (fPTC) and compare them with sporadic papillary thyroid carcinoma (sPTC) in Turkish patients. A retrospective analysis of the papillary thyroid carcinoma (PTC) cases, with or without family history with a follow-up around 10 years was performed. Materials and methods: a series of patients with fPTC (82 fPTC families with 116 affected individuals) were compared with patients with sPTC (n = 112). The clinicopathologic features [(age, gender, histologic subtype, tumour size, bilaterally, multifocality, extrathyroidal extension (FEE), lymph node metastasis (LNM)I and treatment procedures (lymph node dissection, radioactive iodine ablation), and the outcomes like recurrences in the neck region, distant metastasis, and the need for reoperation were compared between the groups. Results: when the groups were compared, there was no significant difference in age (P = 0.449), and tumour size (P 0.898) between familial and sporadic PTC patients. 0,TC group had a significantly higher risk of male gender (P = 0.001), bilaterally (P =0.004), multilocality (P 0.011), LNM (P = 0.013), PTE (P = 0.040), and distant metastasis (P < 0.0001) than the sPTC group. However, recurrence rate was similar between the 2 groups (13 = 0A36). Conclusion: the results of this study confirms a inure aggressive nature in fPTC patients, in terms of bilaterally, nuiltifocality, ETE, LNM, and distant metastasis, compared to sPTC patients in Turkish population.
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    PublicationOpen Access
    Management of endocrine surgical disorders during COVID-19 pandemic: expert opinion for non-surgical options
    (Springer, 2021) Sezer, A.; Makay, O.; Erdoğan, M. F.; Bayram, F.; Güldiken, S.; Raffaelli, M.; Sönmez, Y. A.; Lee, Y.-S.; Vamvakidis, K.; Mihai, R.; Duh, Q.-Y.; Akıncı, B.; Almquist, M.; Barczynski, M.; Bayraktaroğlu, T.; Berber, E.; Bukey, Y.; Çakmak, G. K.; Cantürk, N. Z.; Cantürk, Z.; Çelik, M.; Çelik O.; Ceyhan, B. O.; Cherenko, S.; Clerici, T.; Coombes, D. S.; Demircan, O.; Dionigi, G.; Emre, A. U.; Erbil, Y.; Filiz, A. I.; Gozu, H. I.; Gürdal, S. O.; Gürleyik, G.; Hacıyanlı, M.; Kebudi, A.; Kim, S.; Koutelidakis, G.; Kuru, B.; Mert, M.; Oruk, G. G.; Özbaş, S.; Palazzo, F.; Pandev, R.; Riss, P.; Sabuncu, T.; Şahin, I.; Sakman, G.; Saygılı, F.; Şenyürek, Y. G.; Sleptsov, I.; Van Slycke, S.; Teksöz, S.; Terzioğlu, T.; Tunca, F.; Uğurlu, M. U.; Uludağ, M.; Villar-del-Moral, J.; Vriens, M.; Ağcaoğlu, Orhan; Alagöl, Faruk; Deyneli, Oğuzhan; Dereli, Dilek Yazıcı; Tezelman, Tevfik Serdar; Faculty Member; Faculty Member; Faculty Member; School of Medicine; 175476; N/A; 171914; 179659; N/A
    Purpose: the COVID-19 pandemic brought unprecedented conditions for overall health care systems by restricting resources for non-COVID-19 patients. As the burden of the disease escalates, routine elective surgeries are being cancelled. The aim of this paper was to provide a guideline for management of endocrine surgical disorders during a pandemic. Methods: we used Delphi method with a nine-scale Likert scale on two rounds of voting involving 64 experienced eminent surgeons and endocrinologists who had the necessary experience to provide insight on endocrine disorder management. All voting was done by email using a standard questionnaire. Results: overall, 37 recommendations were voted on. In two rounds, all recommendations reached an agreement and were either endorsed or rejected. Endorsed statements include dietary change in primary hyperparathyroidism, Cinacalcet treatment in secondary hyperparathyroidism, alpha-blocker administration for pheochromocytoma, methimazole ± β-blocker combination for Graves’ disease, and follow-up for fine-needle aspiration results of thyroid nodules indicated as Bethesda 3–4 cytological results and papillary microcarcinoma. Conclusion: this survey summarizes expert opinion for the management of endocrine surgical conditions during unprecedented times when access to surgical treatment is severely disrupted. The statements are not applicable in circumstances in which surgical treatment is possible.