Researcher:
Ünal, Ömer Faruk

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Ömer Faruk

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Ünal

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Ünal, Ömer Faruk

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2015 - 201972020 - 20224

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    Angiolymphoid hyperplasia with eosinophilia of the maxillary sinus and orbit
    (Modestum Ltd, 2017) Emre, İsmet Emrah; Aksoy, Elif; Ünal, Ömer Faruk; Other; School of Medicine; 199800
    Angiolymphoid hyperplasia with eosinophilia (ALHE) is an inflammatory disorder characterized by benign vasoproliferative lesions. Although these lesions are typically found around the ear and external auditory canal, there are several studies that present cases with ocular involvement. In this report we present the first case of ALHE with ocular and sinus involvement in Turkish literature.
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    The protective effect of thymol against cisplatin-induced ototoxicity: an experimental animal study
    (Anatomi Araştırmaları Derneği, 2017) Doğan, Remzi; Akakın, Dilek; Köroğlu, Kutay; Özer, Ömer Faruk; N/A; Koçak, İlker; Ünal, Ömer Faruk; Aydoğan, Esra; Doctor; Other; Doctor; N/A; School of Medicine; N/A; Koç University Hospital; N/A; Koç University Hospital; N/A; 199800; N/A
    Objective: The aim of this study is to investigate the protective effect of thymol against cisplatin- induced ototoxicity by evaluating audiological, biochemical and histopathological parameters. Materials and methods: Thirty-two male rats were divided into four groups (control, cisplatin, thymol + cisplatin and thymol) including eight rats each. 150 mg/kg/day thymol was given for 5 days orally. Single dose cisplatin(16 mg/kg) was also given via intraperitoneal route. Distortion product otoacoustic emission(DPOAE) and auditory brainstem response(ABR) tests from both ears were performed in all groups at the beginning of the study and also on days 6. Intracardiac blood samples and their cochleas were taken on day 6 for assessment of biochemical and histopathological(including TUNEL) parameters. Results: In audiological assessment, in group 2(cisplatin), there were significant decreases in DPOAE values and significant increases in ABR thresholds on days 6 as compared with other groups. In Groups 1(control), 3(thymol + cisplatin) and 4(thymol) there was no significant difference between the pre- and posttreatment DPOAE and ABR results. In biochemichal analyses, the total oxidant status(TOS) value was significantly higher in group 2(cisplatin) than in the other groups. The total antioxidant status(TAS) value was significantly higher in group 3(thymol+cisplatin) than in group 2. In the histopathological examinations, there was significant reduction of the number of TUNEL-positive cells in the group 3(thymol+cisplatin) compared to the group 2(cisplatin). Conclusions: The audiologic tests, biochemical results and histologic findings revealed that thymol may have protective effect against cisplatin ototoxicity by increase antioxidant levels and reduce oxidative stress parameters. / Amaç: Bu çalışmanın amacı odyolojik, biyokimyasal ve histolojik parametreler ile timolün sisplatin ototoksisitesine karşı koruyucu etkisini araştırmaktır. Gereç ve yöntem: 32 sıçan 4 gruba ayrılmıştır(kontrol, sisplatin, timol+sisplatin, timol) 150 mg/kg/gün timol 5 gün süreyle oral yoldan, tek doz cisplatin(16 mg/kg) intraperitonel yolla verilmiştir. Sıçanlara çalışmanın başında ve 6. günde, Distortion product otoakustik emisyon(DPOAE) ve auditory brainstem response(ABR) testleri yapılmıştır. Biyokimyasal ve histolojik parametrelerin değerlendirilmesi için 6. Günde intrakardiyak kan örneklemesi yapılmıştır ve sıçan kokleaları diseke edilmiştir. Bulgular: Odyolojik değerlendirmede; grup 2(sisplatin)’de 6. günde, DPOAE değerlerinde anlamlı düşme ve ABR değerlerinde anlamlı yükselme görülmüştür. Grup 1(kontrol), grup3(timol+sisplatin) ve grup 4(timol)’ de tedavi öncesi ve sonrası DPOAE ve ABR değerlerinde anlamlı fark yoktur. Biyokimyasal Analizde; diğer gruplara göre grup 2(sisplatin)’de total oxidant status(TOS) değeri anlamlı olarak yüksektir. Grup 3(timol+sisplatin)’ de total antioxidant status(TAS) değeri grup 2(sisplatin)’ye göre yüksek olarak bulundu. Histopatolojik muayenede; Grup 3(timol+sisplatin)’ de TUNEL pozitif hücre sayısı grup 2(sisplatin)’ye göre azalmış olarak bulundu. Sonuç: Odyolojik testler, biyokimyasal sonuçlar ve histolojik bulgular timolün sisplatin ototoksisitesine karşı koruyucu etki gösterebileceğini göstermiştir.
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    Reconstruction of composit oromandibular defects
    (AVES, 2017) Altınkaya, Altuğ; Yazar, Şükrü; Ertaş, Burak; Korkut, Nazım; Ünal, Ömer Faruk; Other; School of Medicine; 199800
    Objective: Mandibular defects are generally observed as composite defects which soft tissue defects are accompanied to bone defects. This situation may cause difficulties in choosing the surgical method during the reconstruction period. The purpose of this paper is to convey our clinical approach and results on composite mandibular defects. Methods: Eleven patients, applying to our clinic between 2011 and 2015, were operated in a single session with the team of otorhinolaryngology, because of oromandibular cancer. Ten of the patients were male and one was woman. The age range was between 7 and 54 ages (Average age 35.5). Results: While mandibular resection was performed on all patients, skin resection was performed on six patients, mucosa resection was applied on eight patients; and floor of mouth resections on four patients. The occurring composite defects were reconstructed with free fibular flap or free anterolateral thigh flap. In postoperative period total flap loss was observed in one patient, an infection got developed in the flap donor area of one patient. In the long term, distant metastasis was observed in two patients and local relapse in one patient. Discussion: In the repair of composite mandibular defects, fibula free flap can be considered as the first option with regard to its bone length, suitability for osteotomy and low donor area morbidity. However, in these cases, it is necessary to consider the patient's age, health condition, location and type of defect in the determination of the suitable reconstruction method.
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    Can yoga cause benign paroxysmal positional vertigo?
    (Türk Kulak Burun Boğaz ve Baş Boyun Cerrahisi Vakfı, 2017) N/A; N/A; Koçak, İlker; Gökler, Ozan; Aydoğan, Esra; Karanfil, Işıl; Ünal, Ömer Faruk; Doctor; Teaching Faculty; Doctor; Undergraduate Student; Other; N/A; School of Medicine; N/A; School of Medicine; N/A; Koç University Hospital; N/A; Koç University Hospital; N/A; Koç University Hospital; 135447; 311179; N/A; N/A; 199800
    Objectives: This study aims to investigate any correlation between benign paroxysmal positional vertigo (BPPV) and yoga. Patients and Methods: Two groups were compared in the study: group 1 consisting of volunteers who performed yoga at regular intervals (38 females, 16 males; mean age 32.3 years; range 23 to 50 years) and group 2 as the control group (29 females, 25 males; mean age 34.6 years; range 21 to 46 years). All participants have undergone complete audio-vestibular tests and received Dix-Hallpike maneuver for the diagnosis of posterior semicircular canal BPPV and Roll maneuver for the diagnosis of lateral semicircular canal BPPV. The participants with the definitive diagnosis of BPPV were treated with Epley or Lempert maneuver, according to the affected semicircular canal. Results: Benign paroxysmal positional vertigo was diagnosed in one participant in the control group (1.9%) while it was seen in eight participants in the yoga group (14.8%). We observed the posterior canal to be affected in seven out of eight BPPV patients and lateral semicircular canal was affected in the remaining one patient. We found the prevalence of BPPV to be significantly higher in the yoga group compared to the control group (p=0.031). Although there is no correlation observed between the years of yoga performance and development of BPPV (p>0.05), a positive correlation is found between weekly practice hours of yoga and development of BPPV (p=0.009). Conclusion: There is a statistically significant correlation between BPPV and yoga. Therefore, performing yoga might be a risk factor for BPPV. / Amaç: Bu çalışmada benign paroksismal pozisyonel vertigo (BPPV) ile yoga arasındaki ilişki araştırıldı. Hastalar ve Yöntemler: Bu çalışmada iki grup karşılaştırıldı; grup 1 düzenli aralıklarla yoga yapan gönüllü grubu (38 kadın, 16 erkek; ort. yaş 32.3 yıl; dağılım 23-50 yıl) ve grup 2 gönüllü kontrol grubu (29 kadın, 25 erkek; ort. yaş 34.6 yıl; dağılım 21-46 yıl). Tüm katılımcılara posterior semisirküler kanal BPPV tanısı için komple odyovestibüler testlerle birlikte Dix-Hallpike manevrası ve lateral semisirküler kanal BPPV tanısı için Roll manevrası yapıldı. Benign paroksismal pozisyonel vertigo tanısı konulan katılımcılar, etkilenen semisirküler kanala göre Epley veya Lempert manevrası ile tedavi edildi. Bulgular: Benign paroksismal pozisyonel vertigo kontrol grubunda bir katılımcıda (%1.9) saptanırken, yoga grubunda sekiz katılımcıda (%14.8) saptandı. Bu sekiz BPPV hastasının yedisinde posterior kanal tutulumu, birinde ise lateral semisirküler kanal tutulumu izlendi. Yoga yapan grupta BPPV görülme olasılığı kontrol grubuna kıyasla anlamlı olarak yüksek bulundu (p=0.031). Yoga yapma yılı ile BPPV gelişme riski arasında ilişki yokken (p>0.05), haftalık yoga yapma süresi ile BPPV gelişme riski arasında doğru orantılı ilişki saptandı (p=0.009). Sonuç: Yoga ile BPPV arasında istatistiksel olarak anlamlı bir ilişki saptandı. Dolayısıyla yoga yapmak BPPV için bir risk faktörü olabilir.
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    Concomittant occurence of well-differentiated thyroid carcinoma metastasis and chronic lymphocytic leukemia in the same lymph node along with internal jugular vein thrombus: a case report
    (Wolters Kluwer Medknow Publications, 2021) Tezelman, Serdar; Peker, Önder; Çolakoğlu, Bülent; Ferhanoğlu, Burhan T; Sezer, Havva; Dereli, Dilek Yazıcı; Demirkol, Mehmet Onur; Ünal, Ömer Faruk; Dilege, Şükrü; Taşkın, Orhun Çığ; Kapran, Yersu; Aygün, Murat Serhat; Alagöl, Faruk; Teaching Faculty; Faculty Member; Faculty Member; Other; Faculty Member; Faculty Member; Faculty Member; Teaching Faculty; Doctor; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; American Hospital; American Hospital; American Hospital; American Hospital; 154807; 179659; 196946; 199800; 122573; 166686; 168101; 291692; N/A
    Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) is the most common adult leukemia. The coexistence of CLL and papillary thyroid carcinoma (PTC) is extremely rare. PTC sometimes shows microscopic vascular invasion but rarely cause a tumor thrombus in the internal jugular vein (IJV). It is also rare to find both differentiated and poorly differentiated types of thyroid cancer in the same metastatic location. We report a case of 63-year-old Turkish man with history of CLL who had CLL/SLL involvement and PTC metastasis in the same lymph node. Additionally, there was macroscopic metastasis to the IJV with poorly differentiated areas in the removed tumor thrombus. Patient was treated with total thyroidectomy, left radical neck dissection, resection of the left IJV segment that contained the tumor thrombus and radioactive iodine (RAI) therapy. Furthermore, metastatic lesions were found in the brain, lung and bone. Radiotherapy and chemotherapy were performed. However, our patient died approximately 12 months after thyroidectomy. To our knowledge, our present report is the first description with its current features.
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    Subglottic cysts in preterm infants: superficially located cysts versus deeply buried cysts in the mucosa
    (Springer, 2022) Ünsaler, Selin; Gökler, Ozan; Altuntaş, Muzaffer Ozan; Hafız, Ayşenur Meriç; Ünal, Ömer Faruk; Teaching Faculty; Teaching Faculty; Teaching Faculty; Faculty Member; Other; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; 167909; 311179; 169795; 53676; 199800
    Purpose: To analyze the reason for the diversity of the clinical course of subglottic cysts and discuss their pre- and coexistence with subglottic stenosis. Methods: The medical records of patients who were treated for subglottic cysts between 2003 and 2020 were retrospectively reviewed and direct laryngoscopy videos were analyzed to assess the healing patterns of their disease. Results: Of the 15 patients, 10 had a history of intubation in the neonatal period. In 11 patients, the cysts were transparent and well defined, and no recurrence of subglottic cysts occurred after the initial surgery. In four patients, the cysts were located deep in the mucosa and did not have the typical appearance of a cyst, but rather of a stenotic segment; all of them had a history of intubation and three of them required laryngotracheal reconstruction. Conclusion: Transparent, thin-walled superficial subglottic cysts with healthy surrounding mucosa can easily be treated with endoscopic marsupialization; however, the treatment of deep subglottic cysts can be challenging. The coexistence of subglottic cysts and subglottic stenosis is not rare. We point out the need for considering the possibility of a missed deep submucosal cyst in a seemingly refractory case of pediatric subglottic stenosis with atypical endoscopic findings and with a background history of prior intubation.
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    Nasopharyngeal glial heterotopia with intracranial extension: a case report
    (Galenos Yayincilik, 2018) N/A; N/A; N/A; N/A; N/A; Gökler, Ozan; Karanfil, Işıl; Koçak, İlker; Altuntaş, Muzaffer Ozan; Armutlu, Ayşe; Ünal, Ömer Faruk; Teaching Faculty; Undergraduate Student; Doctor; Teaching Faculty; Teaching Faculty; Other; School of Medicine; School of Medicine; N/A; School of Medicine; School of Medicine; School of Medicine; Koç University Hospital; 311179; N/A; N/A; N/A; 133567; 199800
    Nasopharyngeal glial heterotopia is a mass composed of mature neural tissue occurring outside the central nervous system and is extremely rare. the preoperative diagnosis of such a mass in the head and neck region is challenging. in this study, we report a case of a 16-month-old patient presenting with respiratory distress and snoring caused by nasopharyngeal glial heterotopia. Radiologic imaging and histopathology are obligatory for the definitive diagnosis of glial heterotopia. Preoperative evaluation of an intracranial connection is one of the most essential issues in the presence of pediatric nasopharyngeal masses. the gold standard of treatment is surgical excision. Early recognition and early surgical excision by endoscopic or external approach are crucial to relieve respiratory distress and to maintain healthy growth and development.
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    Nasopharyngeal mass diagnosed as transsphenoidal encephalocele in an adult patient
    (Lippincott Williams and Wilkins (LWW), 2015) Ertaş, Burak; Aksoy, Elif Ayanoğlu; Ünal, Ömer Faruk; Other; School of Medicine; 199800
    Transsphenoidal encephalocele, a rare congenital malformation, is generally diagnosed during childhood when investigating the reason for complaints such as nasal obstruction and recurring cerebrospinal fluid fistula. In this adult patient, the authors identified an asymptomatic transsphenoidal encephalocele after requested monitoring of a pedunculated mass detected in the nasopharynx during nasal endoscopy. After evaluation, the authors decided to follow the patient. Few cases of transsphenoidal encephalocele have been reported, and even fewer have been reported in older patients, with no other anomaly or symptoms. The success of surgical treatment for these masses is debatable. The authors did not consider surgery for this asymptomatic case. With this case presentation, the authors wish to emphasize that without making radiologic assessments of any masses identified in a nasopharyngeal examination, it would be inappropriate to perform a biopsy or any intervention.
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    Endonasal choanal atresia repair; evaluating the surgical results of 58 cases
    (Turkish National Pediatric Society, 2021) Bajin, Münir Demir; Önay, Övsen; Günaydin, Rıza Önder; Yücel, Ömer Taşkın; Akyol, Umut; Aydın, Canset; Ünal, Ömer Faruk; Other; School of Medicine; 199800
    Background: choanal atresia is the most common congenital nasal anomaly, with an incidence of 1:5000-1:8000 live births. Atresia can be seen as membraneous, bony or mixed type. When it is bilateral, it is accepted life-threatening, therefore bilateral atresia necessitates immediate intervention. Diagnosis is confirmed by endoscopic examination and computed tomography. The absolute treatment is surgical, and different approaches have been proposed. Methods: herein, we describe our 15-year experience in the treatment of 58 patients of congenital choanal atresia with transnasal endoscopic approach, and we compare the efficacy of placement of an intranasal stent and applying mitomycin while endoscopic microsurgical repair. Results: the study included 41 female patients (71%) and 17 male patients (29%) with congenital CA. The mean age was 3 years ranging from 10 days to 16 years. The atretic plate was bilateral in 24 patients (41%) and unilateral in 34 (59%). The most common atresia type was the mixed type with 29 patients (50%). A total of 17 patients (29%) required postoperative revision(s). Postoperative revisions were more frequent among patients with bilateral CA (50%), and with mixed CA (31%). Stenting was used additionally by surgical correction for 10 patients. After stenting, fibrosis and restenosis was seen in 7 patients (79%). Mitomycin C was applied peroperatively in 8 patients. Restenosis after mitomycin application was seen in 4 patients (50%). Conclusions: by our experience, endoscopic microsurgical repair of atresia proved to be an effective and safe procedure, results compared with adjuvant treatment modalities like stent or mitomycin C use, was not better. Restenosis was the major problem seen after surgical correction.
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    Post endolaryngeal laser surgery carbon granuloma
    (Galenos Yayınevi, 2017) Ertaş, Burak; Emre, İsmet Emrah; Aksoy, Elif; Ulubil, Arif; Güven, Melih Güven; Tanyeri, Hasan; N/A; Ünal, Ömer Faruk; Other; School of Medicine
    Aim: This study was performed to highlight the phenomenon of carbon granulation formation after laser vocal cord surgery. Emphasis was put on the fact that these granulomas closely resemble tumor recurrence and due to the similarity of appearance, histological evaluation is necessary for diagnosis. Methods: This study included 35 male patients presenting to the Acibadem University Hospital with early-stage laryngeal cancer between 2009 and 2013. All patients underwent laser-assisted interventions on the vocal cords. Patient follow-up was continued for two years and granuloma formation or tumor recurrence was noted. Results: During the two-year follow-up period, a total of five patients presented with new vocal cord lesions. One of the cases was determined to be a tumor recurrence. The remaining four were carbon granulomas that regressed during the follow-up period. Conclusion: Although carbon granuloma formation is not very common, it is still frequent enough to be thoroughly discussed in the literature. With laser surgery for early-stage laryngeal cancer becoming more popular every day, the incidence of carbon granulomas is likely to increase. An algorithm for this type of lesion without putting patients' health at risk will be a valuable tool in the near future.