Research Project: Antibakteriyel Ag Nano Partikül Katkılı Yüksek Entropi Alaşımı PVD Filmlerin Geliştirilmesi ve Karakterizasyonu
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Contributors
Funders
ID
TB.00447
Authors
Motallebzadeh, Amir
Researcher
Publications
A comprehensive study of microstructure, mechanical behavior, biocorrosion, and cytotoxicity of RF-PVD deposited Ti1.5ZrTa0.5Nb0.5X0.5 (X: Hf, Mo, and W) refractory high-entropy alloy films on 316L
(Elsevier Sci Ltd, 2023) Motallebzadeh, Amir; Ünal, Uğur; Hashemkhani, Mahshid; Hendessi, Saman; Alamdari, Armin Asghari; Acar, Havva Funda Yağcı; KUYTAM (Koç University Surface Science and Technology Center); Department of Chemistry; Graduate School of Sciences and Engineering; Yes; College of Sciences; GRADUATE SCHOOL OF SCIENCES AND ENGINEERING; Research Center
In this study, Ti1.5ZrTa0.5Nb0.5Hf0.5, Ti1.5ZrTa0.5Nb0.5Mo0.5, and Ti1.5ZrTa0.5Nb0.5W0.5 refractory high-entropy alloys (RHEA) films were deposited on the 316L substrate using radio frequency physical vapor deposition technique (RF-PVD). The structural investigations revealed that deposited RHEA films had an amorphous structure with smooth morphology and granular features that were few to several hundred nanometers in size. The external surfaces of the deposited films were composed of constituent elements in their oxide and/or suboxide forms. The enhanced contact angle, hardness, tribological performance, adhesion and resistance to scratching, biocorrosion resistance, and low release of Ni and Cr ions demonstrated that Ti1.5ZrTa0.5Nb0.5W0.5 might be a suitable protective coating for 316L biomaterials. Additionally, the in vitro cytotoxicity assessment using C2C12 muscle myoblast cells revealed no cytotoxic response and good cell proliferation.
Investigation of microstructure, mechanical properties, and biocorrosion behavior of Ti1.5ZrTa0.5Nb0.5W0.5 refractory high-entropy alloy film doped with Ag nanoparticles
(Elsevier, 2022) Alamdari, Armin Asghari; Motallebzadeh, Amir; Ünal, Uğur; Department of Chemistry; Graduate School of Sciences and Engineering; KUYTAM (Koç University Surface Science and Technology Center); Yes; College of Sciences; GRADUATE SCHOOL OF SCIENCES AND ENGINEERING; Research Center
Even though metallic biomaterials have long been utilized as the key materials in biomedical applications due to their exceptional mechanical properties, corrosion and bacterial infection problems place a limit on their prolonged clinical applications. In order to overcome such problems, surface modification of the implants via exerting a durable and protective coating containing antibacterial agents is crucial. In this study, undoped and Ag-doped Ti1.5ZrTa0.5Nb0.5W0.5 refractory high-entropy alloy (RHEA) films with a thickness of 1.10 mu m were deposited on Ti6Al4V alloys through RF magnetron sputtering technique. The influence of the deposited film and embedding Ag nanoparticles on microstructure, mechanical properties, and electrochemical behavior was investigated. The microstructural findings revealed an amorphous structure with cauliflower-like morphology for deposited films. Coated specimens showed a significant improvement in surface mechanical properties such as elastic modulus and hardness. Doping Ag nanoparticles in the deposited film increased the roughness and contact angle of the specimens due to the evolution of Ag nanoparticles. Furthermore, electrochemical investigations revealed that undoped and Ag-doped deposited films remarkably improved the corrosion resistance of uncoated substrate; after the films deposition process, the corrosion rate of the specimens decreased 2.3-2.8 orders of magnitude compared to the uncoated substrate. Also, embedding Ag nanoparticles notably increased the polarization resistance of deposited films.
In vitro antibacterial and cytotoxicity assessment of magnetron sputtered Ti1.5ZrTa0.5Nb0.5W0.5 refractory high-entropy alloy doped with Ag nanoparticles
(Elsevier, 2022) Alamdari, Armin Asghari; Hashemkhani, Mahshid; Hendessi, Saman; Güner, Pınar Tatar; Acar, Havva Funda Yağcı; Kavaklı, İbrahim Halil; Ünal, Uğur; Motallebzadeh, Amir; N/A; Department of Chemistry; Department of Chemical and Biological Engineering; Graduate School of Sciences and Engineering; KUYTAM (Koç University Surface Science and Technology Center); Yes; College of Engineering; College of Sciences; GRADUATE SCHOOL OF SCIENCES AND ENGINEERING; Research Center
The aim of the current study is to develop and evaluate antibacterial and biocompatible refractory high-entropy alloy (RHEAs) film using RF magnetron sputtering technique. For this purpose, Ti1.5ZrTa0.5Nb0.5W0.5 RHEA film and its Ag nanoparticle doped analog (with an Ag content of 9 atomic %) were deposited on Ti6Al4V substrate. The microstructural characterization revealed the homogenous distribution of the constituent elements and amorphous structure of the deposited films. The antibacterial activity of Ag nanoparticles doped RHEA film was compared with that of undoped film and uncoated Ti6Al4V. The results indicated that doping Ag nanoparticles reduced the colony forming unit of P. Aeruginosa and S. Aureus bacteria by 98.5% and 90.9%, respectively. In addition, healthy C2C12 mouse muscle myoblast cells adhered and proliferated perfectly on the surface of antibacterial Ag nanoparticles doped RHEA film with no indication of toxic effect, demonstrating promising biocompatibility in addition to its strong antibacterial property.
