Publication: Urinary neutrophil gelatinase-associated lipocalin is associated with preeclampsia in a cohort of Turkish women
Program
KU-Authors
KU Authors
Co-Authors
Yüksel, Semra
Özyürek, Şefik Eser
Acar, Deniz Kanber
Özdemir, Çağdaş
Kıyak, Hüseyin
Gedikbaşı, Ali
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Abstract
Purpose: We investigated the optimal cut-off level for urinary neutrophil gelatinase-associated lipocalin (NGAL) in preeclamptic patients to confirm the diagnosis. Methods: Urinary NGAL concentrations were measured by specific enzyme-linked immunosorbent assay (ELISA). Results: Patients with preeclampsia had significantly higher urinary NGAL concentrations than controls (mean: 387 ng/ml vs. 188 ng/ml, respectively; P< 0.001). Using a cutoff value 252 ng/ml for urinary NGAL to confirm diagnosis of preeclampsia, sensitivity, and specificity were 92% and 91%, respectively. Conclusion: Urinary NGAL concentrations were significantly elevated in women with preeclampsia versus normotensive controls.
Source
Publisher
Taylor and Francis
Subject
Obstetrics, Gynecology, Physiology, Peripheral vascular disease
Citation
Has Part
Source
Hypertension in Pregnancy
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Edition
DOI
10.1080/10641955.2019.1621887
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