Publication: Urinary neutrophil gelatinase-associated lipocalin is associated with preeclampsia in a cohort of Turkish women
Program
KU-Authors
KU Authors
Co-Authors
Yüksel, Semra
Özyürek, Şefik Eser
Acar, Deniz Kanber
Özdemir, Çağdaş
Kıyak, Hüseyin
Gedikbaşı, Ali
Advisor
Publication Date
Language
English
Type
Journal Title
Journal ISSN
Volume Title
Abstract
Purpose: We investigated the optimal cut-off level for urinary neutrophil gelatinase-associated lipocalin (NGAL) in preeclamptic patients to confirm the diagnosis. Methods: Urinary NGAL concentrations were measured by specific enzyme-linked immunosorbent assay (ELISA). Results: Patients with preeclampsia had significantly higher urinary NGAL concentrations than controls (mean: 387 ng/ml vs. 188 ng/ml, respectively; P< 0.001). Using a cutoff value 252 ng/ml for urinary NGAL to confirm diagnosis of preeclampsia, sensitivity, and specificity were 92% and 91%, respectively. Conclusion: Urinary NGAL concentrations were significantly elevated in women with preeclampsia versus normotensive controls.
Source:
Hypertension in Pregnancy
Publisher:
Taylor & Francis
Keywords:
Subject
Obstetrics, Gynecology, Physiology, Peripheral vascular disease