Publication: Urinary neutrophil gelatinase-associated lipocalin is associated with preeclampsia in a cohort of Turkish women
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Yüksel, Semra
Özyürek, Şefik Eser
Acar, Deniz Kanber
Özdemir, Çağdaş
Kıyak, Hüseyin
Gedikbaşı, Ali
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Abstract
Purpose: We investigated the optimal cut-off level for urinary neutrophil gelatinase-associated lipocalin (NGAL) in preeclamptic patients to confirm the diagnosis. Methods: Urinary NGAL concentrations were measured by specific enzyme-linked immunosorbent assay (ELISA). Results: Patients with preeclampsia had significantly higher urinary NGAL concentrations than controls (mean: 387 ng/ml vs. 188 ng/ml, respectively; P< 0.001). Using a cutoff value 252 ng/ml for urinary NGAL to confirm diagnosis of preeclampsia, sensitivity, and specificity were 92% and 91%, respectively. Conclusion: Urinary NGAL concentrations were significantly elevated in women with preeclampsia versus normotensive controls.
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Taylor and Francis
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Source
Hypertension in Pregnancy
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DOI
10.1080/10641955.2019.1621887
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