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Permanent URI for this collectionhttps://hdl.handle.net/20.500.14288/3
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Publication Metadata only Effect of the micro-textured piston on the performance of a hermetic reciprocating compressor(Sage Publications Ltd, 2023) Haque, Umar Ul; Department of Mechanical Engineering; Shahzad, Aamir; Lazoğlu, İsmail; Department of Mechanical Engineering; Manufacturing and Automation Research Center (MARC); Graduate School of Sciences and Engineering; College of EngineeringA hermetic reciprocating compressor is one of the most critical parts for the energy efficiency of a household refrigerator. Piston-cylinder contact in the hermetic compressor accounts for most of the energy loss. The tribological performance of the piston-cylinder pair can be enhanced by introducing micro-texturing on the piston surface. In this research, an experimental study is presented to tribologically assess the effect of the micro-textured piston on the performance of the hermetically sealed reciprocating compressor. The micro-texture on the piston surface was prepared by the laser surface texturing method. Four different micro-textures were studied: radial micro-grooves, axial micro-grooves, mesh micro-grooves, and micro-dimples. The textures’ size, shape, and depth were studied using scanning electron microscopy (SEM) and white light interferometry (WLI) techniques. The results were compared with the non-textured piston compressor. It was found that the radial, axial, and mesh micro-grooves pistons have a negative effect on the coefficient of performance of the hermetic reciprocating compressor. However, the piston with the micro-dimples texture increased the compressor's coefficient of performance by 1%. Refrigerant leakage from the piston-cylinder clearance was also investigated and it was observed that micro-dimples on the piston surface decrease the refrigerant leakage by 35% due to the presence of a continuous oil film between piston and cylinder. The compressor's cooling capacity (Qc) was observed to be increased by 1 W in the case of a micro-dimpled piston.Publication Metadata only Development and characterization of skin substitutes from electrospun polycaprolactone/silk fibroin(Sage Publications Ltd, 2023) Yildiz, Gulsah; Arslan, Yavuz Emre; Derkus, Burak; Menceloglu, Yusuf Ziya; Bayar, Gurkan Rasit; Sezgin, Billur; School of MedicineTissue-engineered skin substitutes have great potential to treat chronic wounds and high-degree burns. Existing solutions, such as Integra Dermal Template, are extensively used for skin defects. However, these templates are still lacking in terms of recreating the functionality of the native tissue and providing scarless healing. In this study, polycaprolactone/silk fibroin (PCL/SF)-based nanofibers with varying blends were fabricated and characterized to develop a novel skin substitute. Morphological analysis showed that the nanofiber distribution of each sample was homogenous without showing any beads. In terms of mechanical properties, all the samples other than SF showed sufficient mechanical strength. It was observed that adding a specific amount of SF into the PCL nanofiber improves the tensile strength of the samples due to the introduction of intermolecular interactions from the functional groups of SF. In addition, incorporating SF into PCL improved Young's modulus of the PCL nanofibers since SF provides stiffness and structural integrity to the overall structure. Water contact angle analysis was performed as the hydrophilicity of a biomaterial is a significant factor in cell functionality. Each sample had a contact angle between 33 degrees and 48 degrees, indicating the adequate hydrophilicity of nanofibers for advanced cell proliferation other than PCL. Cell proliferation and viability studies were conducted with the seeding of primary human keratinocytes on the samples. It was examined that scaffolds containing blends of PCL and SF resulted in higher cell proliferation and viability after 7 days compared to pure PCL and SF nanofibers.Publication Metadata only Machine learning-based PHY-authentication without prior attacker information for wireless multiple access channels(Springer, 2024) Department of Electrical and Electronics Engineering; Altun, Ufuk; Başar, Ertuğrul; Department of Electrical and Electronics Engineering; Graduate School of Sciences and Engineering; College of EngineeringPhysical layer (PHY) authentication methods provide spatial security by exploiting the unique channel between two users. In recent years, many studies focused on substituting traditional threshold-based detection mechanisms with machine/deep learning classifiers to solve the threshold selection problem and obtain better detection accuracy. However, these studies assume that receivers have access to spoofer's channel information at the training of the classifier, which is unrealistic for real-time scenarios. In this study, we propose a PHY-authentication architecture for wireless multiple access channels (W-MACs) that removes this assumption and works without any prior information about the spoofer. The proposed method is designed for multi-user systems and is suitable for any classifier model or communication protocol. The feasibility and the performance of the proposed method are investigated via computer simulations and compared with a benchmark model. The results proved the feasibility of the proposed method as it can detect spoofers successfully without requiring spoofers' channel information.Publication Metadata only Tackling the focal shift effect for metalenses(IOP Publishing Ltd, 2024) Department of Physics; Ali, Farhan; Yazdaanpanah, Ramin; Ramazanoğlu, Serap Aksu; Department of Physics; Graduate School of Sciences and Engineering; College of SciencesWe present a theoretical analysis aimed at comprehending and mitigating the focal shift phenomenon in planar dielectric metalenses. To conduct this analysis, we introduce metalens designs consisting of silicon and germanium nanoblocks on a calcium fluoride substrate, operating in the mid-IR frequency range. The lensing performance of these metalenses is investigated using the finite-difference time-domain method, and they operate at wavelengths of 3 and 4 mu m with a polarization conversion efficiency close to unity. Our findings indicate a strong correlation between the focal shift phenomena on dielectric metalenses and the numerical aperture (NA), revealing that increasing the Fresnel number is not always an effective approach to minimizing the focal shift. In contrast to previous studies, we define a critical NA, independent of the lens size, where the focal shift reaches a minimum, resulting in a symmetric focal intensity distribution and ultimately yielding a better-performing metalens. We demonstrate that for NAs greater than the determined critical value, a positive focal shift is observed on planar metalenses, diverging from the conventional negative shift predicted by existing models. Additionally, we show that by selecting a metalens within a specific NA range and with smaller diameters, high focusing efficiencies can be achieved. The focusing efficiency of the studied metalenses is measured as high as 70%, marking one of the best values reported for the IR range to date. These results serve as a guide for improving the agreement between experimental and designed metalens features, enhancing their practical applications.Publication Metadata only EDA2R-NIK signaling in cancer cachexia(Lippincott Williams and Wilkins, 2024) Department of Molecular Biology and Genetics; Ağca, Samet; Kır, Serkan; Department of Molecular Biology and Genetics; Graduate School of Sciences and Engineering; College of SciencesPurpose of review Cachexia is a debilitating condition causing weight loss and skeletal muscle wasting that negatively influences treatment and survival of cancer patients. The objective of this review is to describe recent discoveries on the role of a novel signaling pathway involving ectodysplasin A2 receptor (EDA2R) and nuclear factor kappa B (NF kappa B)-inducing kinase (NIK) in muscle atrophy.Recent findingsStudies identified tumor-induced upregulation of EDA2R expression in muscle tissues in pre-clinical cachexia models and patients with various cancers. Activation of EDA2R by its ligand promoted atrophy in cultured myotubes and muscle tissue, which depended on NIK activity. The non-canonical NF kappa B pathway via NIK also stimulated muscle atrophy. Mice lacking EDA2R or NIK were protected from muscle loss due to tumors. Tumor-induced cytokine oncostatin M (OSM) upregulated EDA2R expression in muscles whereas OSM receptor-deficient mice were resistant to muscle wasting.SummaryRecent discoveries revealed a mechanism involving EDA2R-NIK signaling and OSM that drives cancer-associated muscle loss, opening up new directions for designing anti-cachexia treatments. The therapeutic potential of targeting this mechanism to prevent muscle loss should be further investigated. Future research should also explore broader implications of the EDA2R-NIK pathway in other muscle wasting diseases and overall muscle health.Publication Metadata only Bud14 function is crucial for spindle pole body size maintenance(TUBITAK, 2024) Department of Molecular Biology and Genetics; Girgin, Sevilay Münire; Çaydaşı, Ayşe Koca; Department of Molecular Biology and Genetics; College of Sciences; Graduate School of Sciences and EngineeringBackground/aim: Spindle pole bodies (SPB), the functional equivalent of centrosomes in yeast, duplicate through generation of a new SPB next to the old one. However, SPBs are dynamic structures that can grow and exchange, and mechanisms that regulate SPB size remain largely unknown. This study aims to elucidate the role of Bud14 in SPB size maintenance in Saccharomyces cerevisiae. Materials and methods: We employed quantitative fluorescence microscopy to assess the relative and absolute amounts of SPB structural proteins at SPBs of wildtype cells and in cells lacking BUD14 (bud14∆). Quantifications were performed using asynchronous cell cultures, as well as cultures synchronously progressing through the cell cycle and upon different cell cycle arrests. We also utilized mutants that allow the separation of Bud14 functions. Results: Our results indicate that higher levels of SPB inner, outer, and central plaque proteins are present at the SPBs of bud14∆ cells compared to wildtype cells during anaphase, as well as during nocodazole-induced M-phase arrest. However, during α-factor mediated G1 arrest, inner and outer plaque proteins responded differently to the absence of BUD14. A Bud14 mutant that cannot interact with the Protein Phosphatase 1 (Glc7) phenocopied bud14∆ in terms of SPB-bound levels of the inner plaque protein Spc110, whereas disruption of Bud14-Kel1-Kel2 complex did not alter Spc110 levels at SPBs. In cells synchronously released from α-factor arrest, lack of Bud14-Glc7 caused increase of Spc110 at the SPBs at early stages of the cell cycle. Conclusion: We identified Bud14 as a critical protein for SPB size maintenance. The interaction of Bud14 with Glc7, but not with the Kelch proteins, is indispensable for restricting levels of Spc110 incorporated into the SPBs. © TÜBİTAK.Publication Metadata only Exploration of novel 6,8,9-trisubstituted purine analogues: synthesis, in vitro biological evaluation, and their effect on human cancer cells(Tubitak Scientific & Technological Research Council Turkey, 2024) Polat, Muhammed Fatih; Atalay, Rengul; Tuncbilek, Meral; N/A; Şahin, İrem Durmaz; Koç University Research Center for Translational Medicine (KUTTAM); School of MedicineCancer, a leading global cause of mortality, demands continuous advancements in therapeutic strategies. This study focuses on the design and synthesis of a novel series of purine derivatives, specifically 6 -(substituted phenyl piperazine)-8-(4-phenoxyphenyl)9-cyclopentyl purine derivatives (5-11). The motivation behind this endeavor lies in addressing acquired resistance mechanisms in cancer cells, a significant hurdle in current treatment modalities. The synthesis, starting from 4,6-dichloro-5-nitropyrimidine, involves a multi -step process, resulting in seven new purine derivatives. Biological evaluation against human liver, colon, and breast cancer cells (Huh7, HCT116, and MCF7, respectively) was performed using the SRB assay. Among the synthesized analogs, compounds 5 and 6, exhibited notable cytotoxic activity, surpassing clinically used positive controls 5-Fluorouracil and Fludarabine in terms of efficacy. This research underscores the potential of purine derivatives with a phenyl group at the C-8 position as a scaffold for developing compounds with improved anticancer properties. The findings offer insights for future exploration and development of novel agents in cancer pharmaceutical research.Publication Metadata only Fracture toughness of AlTiN coatings investigated by nanoindentation and microcantilever bending(Elsevier Science Sa, 2024) Kaygusuz, Burcin; Karadayi, Ozcan; Kazmanli, Kuersat; Ozerinc, Sezer; N/A; Motallebzadeh, Amir; Koç University Surface Science and Technology Center (KUYTAM); N/AMetal nitride coatings are increasingly used in MEMS applications. The brittle nature of these coatings makes fracture one of the main failure mechanisms during operation. Therefore, quantifying the fracture toughness of nitride coatings in a reliable fashion is important to understand the failure behavior and to optimize device performance and reliability. This study investigated the fracture toughness of AlTiN coatings produced by cathodic arc evaporation, a widely used technique in the industry. Nanoindentation and microcantilever bending-based measurements indicated a fracture toughness of 6.6 and 4.8 MPa & sdot;m1/2, respectively. The lower toughness results of microcantilever bending were attributed to the columnar growth of the coating, which promoted crack propagation perpendicular to the film surface. The results provide useful data toward a better understanding of the fracture of hard coatings and give insight into the advantages and disadvantages of different measurement methods.Publication Metadata only Probing water adsorption characteristics of Pt step-edge decorated CU (211) surface(Elsevier, 2024) Department of Chemistry; Mohammadpour, Amin; Kaya, Sarp; Department of Chemistry; Koç University Tüpraş Energy Center (KUTEM); College of Sciences; Graduate School of Sciences and EngineeringThe surface structure and atomic composition can affect the adsorption characteristics of water on metal surfaces. In this study, we investigated the adsorption of water on Cu(211) stepped surfaces decorated with Pt by a combination of infrared reflection absorption spectroscopy (IRRAS) and temperature -programmed desorption (TPD) studies. We have observed that step sites of Cu can increase the strength of the binding of water molecules to the surface and facilitate water partial dissociation and the formation of OH groups on the surface. Step decoration by Pt can change the water adsorption characteristics and eliminate the water dissociation. Water adsorbs molecularly on the fully Pt -decorated steps of the Cu(211) surface. Molecular water and OH adsorbed on Cu(211), which can make a chain structure, are disrupted with Pt atoms.Publication Metadata only Using Auger transitions as a route to determine the oxidation state of copper in high-pressure electron spectroscopy(Elsevier, 2024) Soldemo, Markus; Garcia-Martinez, Fernando; Goodwin, Christopher M.; Loemker, Patrick; Shipilin, Mikhail; Nilsson, Anders; Amann, Peter; Weissenrieder, Jonas; Department of Chemistry; Kaya, Sarp; Department of Chemistry; Koç University Tüpraş Energy Center (KUTEM); College of SciencesAccurate discrimination between metallic copper (Cu0) and cuprous oxide (Cu2O, Cu+) in electron spectroscopy commonly relies on the Auger electron spectroscopy (AES) Cu L3M4,5M4,5 transitions, as the X-ray photoelectron spectroscopy (XPS) Cu core-levels do not provide large enough binding energy shifts. The kinetic energy of the AES Cu L3M4,5M4,5 electrons is 917 eV, which leaves the AES electron susceptible for efficient scattering in the gas phase and attenuation of the signal above near-ambient pressure conditions. To study copper-based materials at higher pressures, e.g., the active state of a catalyst, Auger transitions providing electrons with higher kinetic energies are needed. This study focuses on AES transitions involving the Cu K-shell (1s electrons) that exhibit discernible kinetic energy shifts between the oxidation states of Cu. It is shown that the AES Cu KL2M4,5 transition, with kinetic energy of 7936 eV, provides a large enough kinetic energy shift between metallic copper and Cu2O. AES signal is demonstrated in an ambient of 150 mbar CO2.