Researcher:
Şahin, Selin Merve

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Undergraduate Student

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Selin Merve

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Şahin

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Şahin, Selin Merve

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2021 - 20225

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    Antibacdus-pan: antibacterial utilization among adult patients at Koc University Hospital before and during COVID-19 pandemic within 12-months period: a hospital pharmacoepidemiology study
    (Wiley, 2022) Gülmez, Sinem Ezgi; Güldan, Mustafa; Uçar, Ege Anıl; Karakuş, Mehmet Batuhan; Şahin, Selin Merve; Şişman, Uluman; Baygül, Arzu Eden; Faculty Member; Undergraduate Student; Undergraduate Student; Undergraduate Student; Undergraduate Student; Undergraduate Student; Undergraduate Student; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; School of Medicine; 281312; N/A; N/A; N/A; N/A; N/A; 272290
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    PublicationOpen Access
    Antipacdus-pan: antibacterial utilization among adult patients before and during COVID-19 Pandemic within 12-months period: a tertiary hospital pharmacoepidemiology study
    (Design Oriented Community (DOC), 2022) Uçar, Ege Anıl; Karakuş, Mehmet Batuhan; Güldan, Mustafa; Şahin, Selin Merve; Şişman, Uluman; Baygül, Arzu Eden; Gülmez, Sinem Ezgi; Undergraduate Student; Undergraduate Student; Undergraduate Student; Faculty Member; Koç University Research Center for Translational Medicine (KUTTAM) / Koç Üniversitesi Translasyonel Tıp Araştırma Merkezi (KUTTAM); School of Medicine; N/A; N/A; N/A; N/A; N/A; 272290; 281312
    Objective: irrational use of antibacterials is a concern during the COVID-19 pandemic. Hospital pharmacoepidemiology studies are important for evaluating the rational use of medicines, especially antibacterials, during pandemics. Defined daily doses (DDD) and drug utilization 90% (DU90%) are established methods for the evaluation of drug utilization. We aimed to evaluate antibacterial utilization in a tertiary hospital setting at Koç University Hospital (KUH). Materials and methods: this cross-sectional, descriptive study was retrospectively conducted with data extracted from KUH Inpatient Electronic Order System (CP) and was carried out for a period of one year. Antibacterial utilization of adult (aged ? 18 years) inpatients, who were prescribed at least one type of systemic antibacterial (ATC code J01), was evaluated using the recommended parameter DDD/100 admission and compared between 6 months before COVID-19 and during COVID-19 periods. March 11, 2020, the very first COVID-19 diagnosed case in Turkey, was set as the cutoff date of the 6-month period for the selection of the compared antibacterials using the DU90% method. Results: finally, 3280 of 5942 and 2605 of 4942 prescriptions for pre-COVID-19 and COVID-19 periods were included, respectively. Antibacterial utilization according to DDD/100 admissions increased from 193.96 to 201.26 DDD/100 admissions after the initiation of COVID-19 pandemic. The most utilized antibacterials were piperacillin and enzyme inhibitors in pre-COVID-19 period, whereas meropenem was utilized the most during COVID-19 period. Azithromycin utilization increased by 656.24%, whereas clarithromycin utilization decreased by 52.12%. Antibacterials were utilized most in general surgery department, with an increase of 17.57%. Conclusion: there is an increase in antibacterial utilization in KUH during COVID-19 pandemic, especially reserved antibacterials, which is a concern for antibacterial resistance.
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    PublicationOpen Access
    The effect of COVID-19 pandemic on sudden idiopathic sensorineural hearing loss: a cross-sectional study in a single institution
    (Bayçınar Tıbbi Yayıncılık ve Reklam Hizmetleri, 2022) Ünsaler, Selin; Hafız, Ayşenur Meriç; Şahin, Selin Merve; Aydoğan, Esra; Gökler, Ozan; Altuntaş, Muzaffer Ozan; Faculty Member; Undergraduate Student; Teaching Faculty; Teaching Faculty; School of Medicine; Koç University Hospital; 167909; N/A; N/A; N/A; 311179; 169795
    Objectives: this study aimed to evaluate the effects of the coronavirus disease 2019 (COVID-19) pandemic on the incidence, course, and prognosis of sudden idiopathic sensorineural hearing loss (SISNHL). Patients and methods: this retrospective study was conducted with 55 patients (31 males, 24 females; mean age: 44.4±18.5 years; range, 11 to 83 years) treated for SISNHL. The patients were analyzed in two groups: Group 1, which included 35 patients (24 males, 11 females; mean age: 42.5±18.8 years; range, 11 to 72 years) admitted after the onset of the pandemic between March 2020 and March 2021, and Group 2, which consisted of 20 patients (7 males, 13 females; mean age: 47.5±19.0 years; range, 20 to 83 years) admitted before the pandemic between March 2019 and February 2020. Age, the timing of referral to the otolaryngology clinic after the perception of the first otologic symptom, the severity of the hearing loss, and the status of recovery were investigated. The COVID-19 status of Group 1 was investigated. Results: the incidence of SISNHL among all patients admitted to our clinic in the same time duration was found to have increased after the COVID-19 pandemic, and this increase was statistically significant (p=0.04). One patient had SISNHL during acute COVID-19. Three patients had COVID-19 three weeks before SISNHL, six patients had COVID-19 three months before SISNHL, and one patient was diagnosed with COVID-19 six months before SISNHL. Fourteen patients were tested for severe acute respiratory syndrome coronavirus 2 with real-time polymerase chain reaction at the time of admission, which resulted in negative. Conclusion: as the incidence of SISNHL has increased following the COVID-19 pandemic, a possible relation between hearing loss, presenting as SISNHL, and COVID-19 disease should be investigated. / Amaç: bu çalışmada, koronavirüs hastalığı 2019 (COVID-19) pandemisinin ani idiyopatik sensörinöral işitme kaybının (AİSİK) insidansı, seyri ve prognozu üzerindeki etkileri değerlendirildi. Hastalar ve yöntemler: bu retrospektif çalışma, AİSİK için tedavi edilen 55 hasta (31 erkek, 24 kadın; ort. yaş: 44.4±18.5 yıl; dağılım, 11-83 yıl) ile yürütüldü. Hastalar iki grupta analiz edildi: Mart 2020 ile Mart 2021 arasında pandemi başlangıcından sonra başvuran 35 hastadan (24 erkek, 11 kadın; ort. yaş: 42.5±8.8 yıl; dağılım, 11-72 yıl) oluşan Grup 1 ve Mart 2019 ile Şubat 2020 arasında pandemi öncesi başvuran 20 hastadan (7 erkek, 13 kadın; ort. yaş: 47.5±19.0 yıl; dağılım, 20-83 yıl) oluşan Grup 2. Yaş, ilk otolojik semptomun algılanmasından sonra kulak burun boğaz polikliniğine başvuru zamanlaması, işitme kaybının şiddeti ve iyileşme durumu araştırıldı. Grup 1’in COVID-19 durumu araştırıldı. Bulgular: kliniğimize aynı süre içinde başvuran tüm hastalarda AİSİK insidansının COVID-19 pandemisi sonrası arttığı saptandı ve bu artış istatistiksel olarak anlamlıydı (p=0.04). Bir hastada akut COVID-19 sırasında AİSİK gelişti. Üç hastada AİSİK’den üç hafta önce COVID-19 vardı, altı hastada AİSİK’den üç ay önce COVID-19 vardı ve bir hastada AİSİK’den altı ay önce COVID-19 tanısı konulmuştu. On dört hasta başvuru sırasında şiddetli akut solunum yolu sendromu koronavirüsü 2 için gerçek zamanlı polimeraz zincir reaksiyonu ile test edildi ve sonuç negatif çıktı. Sonuç: COVID-19 pandemisini takiben AİSİK insidansı arttığı için AİSİK olarak ortaya çıkan işitme kaybı ile COVID-19 hastalığı arasındaki olası ilişki araştırılmalıdır.
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    PublicationOpen Access
    Pediatric laryngeal measurements based on computed tomography images
    (Aves, 2022) Ünsaler, Selin; Gökler, Ozan; Aygün, Murat Serhat; Şahin, Selin Merve; Yaycıoğlu, Arda; Altuntaş, Muzaffer Ozan; Ünal, Ömer Faruk; Hafız, Ayşenur Meriç; Teaching Faculty; Teaching Faculty; Undergraduate Student; Other; Faculty Member; School of Medicine; Koç University Hospital; 167909; N/A; N/A; N/A; N/A; N/A; N/A; N/A
    Background: this study aimed to establish average laryngeal measurements in the Turkish pediatric population and measure the narrowest portion of the pediatric airway. Methods: the laryngeal measurements of 88 pediatric patients between the ages 0 and 17 were retrospectively obtained from neck computed tomography scans performed between January 2018 and May 2021. Subjects were divided into 6 age groups. Four following measurements were made: cricoid anteroposterior, cricoid transverse, subglottic anteroposterior, and subglottic transverse. Cross-sectional areas were calculated using these dimensions. Subglottic cross-sectional area/cricoid crosssectional area ratio for each subject was calculated and patients were divided into 2 groups: group 1, subjects with ratio < 1; group 2, subjects with ratio ? 1. Results: mean age was 8.97 ± 5.7. Mean anteroposterior diameters at subglottis and cricoid ring levels were 13.74 ± 4.45 mm and 13.26 ± 4.39 mm; mean transverse diameters were 7.88 ± 2.62 mm and 9.06 ± 3.12 mm, respectively. The subglottic anteroposterior diameter was greater than cricoid (P < .001), but the transverse diameter was smaller than cricoid (P < .001). Subglottic cross-sectional area was 93.24 ± 59.20 mm2 and cricoid cross-sectional area was 103.61 ± 69.15 mm2 . Subglottic cross-sectional area/cricoid cross-sectional area ratio was smaller than 1 in 69 subjects (group 1; mean=0.85) and equal to or greater than 1 in 19 subjects (group 2; mean=1.33). Conclusion: the narrowest portion of the airway was subglottis immediately below the vocal cords, in contrast to the common belief as to the cricoid ring. Subglottic cross-sectional area/cricoid cross-sectional area ratios showed that the pediatric airway was larger at cricoid (69 subjects, 78.4%), and this ratio does not differ based on age.
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    PublicationOpen Access
    Molecular communication theoretical modeling and analysis of SARS-CoV2 transmission in human respiratory system
    (Institute of Electrical and Electronics Engineers (IEEE), 2021) Koca, Çağlar; Department of Electrical and Electronics Engineering; Civaş, Meltem; Şahin, Selin Merve; Ergönül, Önder; Akan, Özgür Barış; Undergraduate Student; Faculty Member; Faculty Member; Department of Electrical and Electronics Engineering; Graduate School of Sciences and Engineering; School of Medicine; College of Engineering; N/A; N/A; 110398; N/A
    Severe Acute Respiratory Syndrome-CoronaVirus 2 (SARS-CoV2) caused the ongoing pandemic. This pandemic devastated the world by killing more than a million people, as of October 2020. It is imperative to understand the transmission dynamics of SARS-CoV2 so that novel and interdisciplinary prevention, diagnostic, and therapeutic techniques could be developed. In this work, we model and analyze the transmission of SARS-CoV2 through the human respiratory tract from a molecular communication perspective. We consider that virus diffusion occurs in the mucus layer so that the shape of the tract does not have a significant effect on the transmission. Hence, this model reduces the inherent complexity of the human respiratory system. We further provide the impulse response of SARS-CoV2-ACE2 receptor binding event to determine the proportion of the virus population reaching different regions of the respiratory tract. Our findings confirm the results in the experimental literature on higher mucus flow rate causing virus migration to the lower respiratory tract. These results are especially important to understand the effect of SARS-CoV2 on the different human populations at different ages who have different mucus flow rates and ACE2 receptor concentrations in the different regions of the respiratory tract.